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Research reveals why cancers stop responding to kinase-blocking drugs and come back stronger
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Research reveals why cancers stop responding to kinase-blocking drugs and come back stronger

by New York University Structure of the FGFR kinase showing the locations of the gatekeeper residue in blue, hydrophobic spine in yellow, and ATP in cyan. Most drugs bind to the kinase in the same pocket as ATP. Credit: Traaseth Lab/NYU More than 70 FDA-approved cancer drugs are kinase inhibitors, which work by blocking kinases—enzymes that...