by Virginia Commonwealth University KRB-456 inhibits the growth in vivo of orthotopic mt KRAS tumors derived from pancreatic cancer patients. Tumor biopsies from pancreatic cancer patient G160 were prepared and implanted orthotopically into NSG mice as described in Methods. On day 20 after implantation, mice were treated i.p. daily for 30 days with vehicle or 5mpk...
