by Johannes Angerer, Medical University of Vienna Figure S1. Sunburst plot showing the classes of drugs tested by scFPM. Drugs can be broadly classified into kinase inhibitors, immunomodulatory drugs, epigenetic modifiers, metabolic modifiers, apoptotic modulators, classical chemotherapeutics and other drugs. Credit: DOI: 10.1158/2159-8290.CD-21-0538 Standard therapy for advanced recurring aggressive, hematological malignancies, such as leukemias and lymphomas,...
by University of Bonn Graphical abstract. Credit: DOI: 10.1016/j.patter.2021.100351 The presence of cancer of the lymphatic system is often determined by analyzing samples from the blood or bone marrow. A team led by Prof. Dr. Peter Krawitz from the University of Bonn had already shown in 2020 that artificial intelligence can help with the diagnosis of...
by Linköping University TET2 is a novel tumor suppressor in T-ALL. (A) Mutations in TETs and IDHs in primary human T-ALL from a meta-analysis of nine studies including 854 patients. (B) Known TET2 isoforms, TET2a (red) and TET2b (blue). (C) Expression of TET2 isoforms in 27 healthy tissues from the Human Protein Atlas. (D) Expression of...
PHILADELPHIA—A CRISPR screening tool identified a new therapeutic target to treat acute myeloid leukemia (AML) that has the potential to leave patients with fewer side effects than current approaches, according to a new study from Penn Medicine published online in Molecular Cell. The target, known as ZMYND8, isn’t a mutated gene, rather an epigenetic regulatory protein that cancer cells need...
by University Health Network Credit: Unsplash/CC0 Public Domain For the first time, Princess Margaret researchers have mapped out where and how leukemia begins and develops in infants with Down syndrome in preclinical models, paving the way to potentially prevent this cancer in the future. Children with Down syndrome have a 150-fold increased risk of developing myeloid leukemia within...
UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS IMAGE: ERIC PIETRAS, PH.D., AND JAMES DEGREGORI, PH.D. CREDIT: CU CANCER CENTER Two recent collaborative publications by CU Cancer Center members provide insights into how chronic inflammation can serve as a key factor in the development of leukemia and other blood cancers. Eric Pietras, Ph.D., CU Cancer Center member...
by St. Jude Children’s Research Hospital First authors Lindsey Montefiori, Ph.D., (foreground) and Xiaolong Chen, Ph.D., helped identify gene alterations that drive subsets of acute leukemias in children and adults in a joint study with Munich Leukemia Laboratory. Credit: St. Jude Children’s Research Hospital Researchers have identified gene alterations that drive a subset of acute leukemias...
by Northwestern University Bone marrow aspirate showing acute myeloid leukemia. Several blasts have Auer rods. Credit: Wikipedia A team of Northwestern Medicine scientists led by Ali Shilatifard, Ph.D., the Robert Francis Furchgott Professor and chair of Biochemistry and Molecular Genetics, has identified the molecular mechanisms of ASXL1 mutations involved in leukemia pathogenesis, according to a study...
by Adrienne Williamson , Medical Xpress This lighthearted cartoon, supplied by Chi Wai Eric So, PhD., illustrates the research’s key finding: the repositioning of a diarrheal drug for leukemia treatment. Credit: Emily Zeisig New research into one of the most common and difficult cancers to treat has revealed an effective route to mitigating chemotherapy resistance through the use...
by Center for Genomic Regulation Image of stem cells (blue) in bone marrow together with a sinusoidal blood vessel (red) and an arteriolar blood vessel. Single cell sequencing is a promising method because it can help discriminate between healthy stem cells and potentially cancerous ones that cannot be identified via imaging. Credit: Jude Al-Sabah/DKFZ A...
