by University Health Network Dr. Benjamin Haibe-Kains is the joint corresponding author for the study “Biological and therapeutic implications of a unique subtype of NPM1 mutated AML”, published in Nature Communications. Credit: The Princess Margaret Cancer Foundation Using advanced RNA sequencing, scientists have identified two unique subtypes of a prominent mutation present in many patients with Acute...
by Yale University Bone marrow aspirate showing acute myeloid leukemia. Several blasts have Auer rods. Credit: Wikipedia In a new study led by Yale Cancer Center, researchers have discovered a novel metabolic gatekeeper mechanism for leukemia. This mechanism depends on a molecule called PON2, which could lead to a new treatment for the disease. The findings were published...
by Max Planck Society Bone marrow aspirate showing acute myeloid leukemia. Several blasts have Auer rods. Leukemia frequently originates from the so-called leukemic stem cell, which resides in a tumor promoting and protecting niche within the bone marrow. Scientists from the Max Planck Institute of Biochemistry in Martinsried, Germany, have found a new way to make...
by Temple University Bone marrow aspirate showing acute myeloid leukemia. Several blasts have Auer rods. Like packaging designed to create a protective environment around a product, the mix of cells and fluids immediately surrounding human bone marrow provides critical protective and nourishing conditions for hematopoietic—or bone marrow-originating—stem cells. Immune cells and other specialized components native to...
HIROSHIMA UNIVERSITY IMAGE: CML STEM CELLS, WHICH ARE THE CELLULAR SOURCE OF THE VAST MAJORITY OF CML CELLS, ARE REPORTEDLY RESISTANT TO TKI THERAPY DUE TO THE STEM CELL QUIESCENCE. THUS, THE REMAINING. Researchers have identified a second path to defeating chronic myelogenous leukemia, which tends to affect older adults, even in the face of...
by University of Montreal Researchers discovered 5000 genetic associations and used the genetic diversity of their samples to refine association signals and explored the genetic architecture of blood-cell traits across populations. This image illustrates how the authors used genetic data from 746,667 participants from five global populations (African-ancestry, East Asian, European-ancestry, Latino/Hispanic, South Asian) to...
Acute myeloid leukemia (AML) is a hematological malignancy which incidence increases with age, that is biologically, phenotypically, and genetically very heterogeneous. Its treatment uses to combine chemotherapy followed by allogenic Hematopoietic Stem and Progenitor Cells transplant (allo-HSCT), based on the patient’s eligibility, to consolidate complete remission and prevent relapse. Yet, except for a few subgroups,...
Study suggests the benefits of a more personalized therapy typically outweigh the risks of delaying treatment to await test results AMERICAN SOCIETY OF HEMATOLOGY PRINT E-MAIL New tailored therapies offer exciting prospects for treating acute myeloid leukemia (AML), but taking advantage of them may require waiting a week or more for genetic testing before starting...
The immune system is one of the most powerful tools we have in the fight against cancer, but sometimes it needs a little extra help. In a new study from the Peter MacCallum Cancer Centre, researchers have developed a new way to summon a wider variety of immune cells to target tumors. One of the...
How do you stay safe now that states are reopening? An expert explains how to assess risk when reconnecting with friends and family May 18, 2020 8.20am EDT Author Ryan Malosh Assistant Research Scientist, University of Michigan Disclosure statement Ryan Malosh receives salary support from the Centers for Disease Control and Prevention (CDC) and the...
