Reviewed by James Ives, M.Psych. (Editor) An anticancer drug of fungal origin could be the way. Scientists at Waseda University succeeded in developing a method for a total synthesis of cotylenin A, a plant growth regulator which has attracted considerable attention from the scientific community due to its promising bioactivity as an anti-cancer agent. This...
Tag: <span>Leukemia</span>
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Finding leukemia’s weakness using genome-wide CRISPR technology
A team of researchers at University of California San Diego School of Medicine and Moores Cancer Center used CRISPR technology to identify key regulators of aggressive chronic myeloid leukemia, a type of cancer that remains difficult to treat and is marked by frequent relapse. “We used CRISPR technology to carry out a genome-wide screen in...
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Scientists discover how rogue communications between cells lead to leukemia
by University of York New research has deciphered how rogue communications in blood stem cells can cause leukaemia. The discovery could pave the way for new, targeted medical treatments that block this process. Blood cancers like leukaemia occur when mutations in stem cells cause them to produce too many blood cells. An international team of...
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Leukemia’s unexpected link to vitamin B-6
Researchers have discovered a new target for leukemia treatment after their study revealed that cancerous cells utilize vitamin B-6. The development of a new drug that could prove to be more effective than current treatments is underway. Researchers hope that exploiting leukemia’s reliance on B6 might lead to better treatments. Leukemia — a form of...
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Cheap drug may alleviate treatment-resistance in leukemia
KAROLINSKA INSTITUTET A common and inexpensive drug may be used to counteract treatment resistance in patients with acute myeloid leukemia (AML), one of the most common forms of blood cancer. This is the conclusion of a study in mice and human blood cells performed at Karolinska Institutet and SciLifeLab and published in the medical journal...
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Leukemia, lymphoma squarely in sights of new class of drugs
UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO UT Health San Antonio researchers, working with collaborators at the University of Florida, have discovered a safe and potent next generation of drugs to fight multiple types of leukemia and lymphoma in adults and children. The journal Nature Medicine reported the findings Dec. 2. “This is...
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DRUG COCKTAIL PROVES TOXIC TO LEUKEMIA
A combination of drugs that affect mitochondria—the power plants inside cells—may become the best weapons yet to fight acute myeloid leukemia, according to new research. Researchers found that mitocans, anti-cancer drugs that target mitochondria, are particularly adept at killing leukemia cells, especially when combined with a glycolytic inhibitor, while leaving healthy blood cells in the...
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Infant with deadly leukemia saved by drug for adult liver cancer
by University of California, San Francisco UCSF Benioff Children’s Hospitals have successfully treated a months-old infant with a rare childhood leukemia using a targeted therapy approved for adults with inoperable liver cancer and advanced kidney cancer. The decision to use the drug, sorafenib, was made after pathologists identified a unique mutation in the form of...
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FDA approves venetoclax for chronic, small lymphocytic leukemia
Data from CLL14, a randomized, multicenter, open-label, actively controlled trial, provided the basis for approval. CLL14 involved 432 patients with previously untreated CLL and coexisting medical conditions who were randomly assigned to venetoclax plus obinutuzumab (VEN+G) or obinutuzumab plus chlorambucil (GClb). The researchers observed a statistically significant improvement in progression-free survival for patients who received VEN+G compared with those...
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Starving leukemia cells by targeting amino acids
Altered metabolism in cancer cells EMORY HEALTH SCIENCES Cancer cells consume sugar at a higher rate than healthy cells, but they’re also hungry for amino acids, the building blocks of proteins and other biomolecules. Researchers at Winship Cancer Institute of Emory University have discovered a way to exploit that hunger to selectively block the growth of leukemias. The results were published...