by University of Birmingham AML-subtype specific gene expression and chromatin accessibility is established in LSCs. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-45691-4The mystery of why myeloid leukemia starts to grow again after chemotherapy has killed the bulk of malignant cells, and how growth may be blocked by repurposed drugs, has potentially been solved through new research. The...
INSELSPITAL, BERN UNIVERSITY HOSPITAL IMAGE: ACTIVATED LIGHT/LTBR SIGNALING PATHWAY (LEFT) LEADS TO SYMMETRIC CLEAVAGE AND A PROPATATION OF LEUKEMIC STEM CELLS. CREDIT: A. OCHSENBEIN, UNIVERSITY HOSPITAL BERN Leukemia is caused by leukemic stem cells which are resistant to most known therapies. Relapses are also due to this resistance. Leukemic stem cells arise from normal blood-forming...
Acute myeloid leukaemia is the most common type of leukaemia in adults. It is characterized by the pathological expansion of immature cells (myeloblasts) that invade the bone marrow and expand into the blood, affecting the production of the rest of the healthy cells. Although patients usually respond well to chemotherapy-based treatments, a large proportion of...
