by University of Chicago Medical Center Loss of BNIP3 promotes HCC initiation and tumor growth. (A) Representative images of HCC tumors forming in the liver of Bnip3+/+ and bnip3−/− mice at 24 and 40 weeks of age following DEN injection. Scale bars, 12.7 mm. (B) Graph of tumor number forming in the liver of Bnip3+/+ (red) and bnip3−/− (blue)...
Understanding the molecular details of protein function allows researchers to identify critical residues that can be targeted with rational drug design to develop better cancer therapeutics MEDICAL UNIVERSITY OF SOUTH CAROLINA Normal cells have a complex system of checks and balances that regulate cell division. In cancer, the balance is tipped in favor of cell proliferation. This imbalance arises from...
How can elimination of therapeutics from the bloodstream or their early enzymatic degradation be avoided in systemic delivery? Chinese scientists have new developed a method to bind an established cancer therapeutic, floxuridine, with natural serum albumin for its transport and delivery to target cancer cells. In the journal Angewandte Chemie, the authors demonstrate the automated synthesis...
