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Researchers uncover how sugar substitutes disrupt liver detoxification
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Researchers uncover how sugar substitutes disrupt liver detoxification

by Experimental Biology  Non-nutritive sweeteners (NNS) consumed in the diet enter the liver from the blood circulation. Researchers found that in liver cells, the detoxifying transporter P-glycoprotein (PGP) exports NNS preferentially to several known substrate compounds. In a physiological context, this could leave other PGP substrates such as certain medications trapped in cells, potentially leading...