EUROPEAN SOCIETY OF ENDOCRINOLOGY Press release – Abstract 481: Effects of testosterone therapy on morphology and grade of NAFLD in obese men with functional hypogonadism and type 2 diabetes According to a new study, testosterone therapy may reduce non-alcoholic fatty liver disease in obese men with functional hypogonadism and type-2 diabetes. Testosterone therapy may help...
Tag: <span>liver disease</span>
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Cytoglobin: key player in preventing liver disease
OSAKA CITY UNIVERSITY IMAGE: 6His tagged recombinant human CYGB (His-CYGB) was endocytosed into the HSCs via Clathrin-mediated pathway, scavenged ROS, such as O2- and OH-, and induced IFN-β secretion mediated by TANK binding kinase 1 (TBK1), resulting in HSC deactivation and inhibition of αSMA and collagen gene expressions in vitro and in vivo. In total,...
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CT identifies patients with high-risk nonalcoholic fatty liver disease (NAFLD)
AMERICAN ROENTGEN RAY SOCIETY IMAGE: A and B, True-positive assessments in 58-year-old woman (A) and 52-year-old man (B) with high-risk NAFLD and associated NASH. CT images show hepatic enlargement, heterogeneously low-attenuation hepatic parenchyma, and surrounding ascites. Readers correctly identified NASH according to these imaging features. Readers also correctly identified fibrosis stage F3. C and D,...
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A gene mutation that protects against disease
by McMaster University Credit: CC0 Public Domain Canadian scientists looking at a rare genetic mutation think they may have discovered the proverbial fountain of youth. But it’s not for everyone: so far, the mutation has only been found in a handful of French-Canadian families. Called PCSK9Q152H, the mutation of the PCSK9 gene was initially thought to...
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Fecal transplants may reduce alcohol use, early research suggests
by Jackie Kruszewski, Virginia Commonwealth University A Virginia Commonwealth University researcher has published preliminary but striking evidence that shows the transplantation of gut bacteria may have implications for addiction disorders. Jasmohan Bajaj, M.D., a gastroenterologist and liver specialist, transplanted bacteria from another person’s stool into 10 volunteers with severe alcohol use disorder and cirrhosis. Nine...
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Osteopontin, a protein not always as bad as it is made out to be
The UPV/EHU-University of the Basque Country shows that maintaining osteopontin delays the onset of metabolic fatty liver disease during ageing UNIVERSITY OF THE BASQUE COUNTRY THE STUDY INDICATES THAT OSTEOPONTIN IS NECESSARY TO PREVENT THE EARLY ONSET OF NON-ALCOHOLIC FATTY LIVER DISEASE LINKED TO AGEING view more Metabolic fatty liver disease, known as non-alcoholic fatty...
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Strong link found between abnormal liver tests and poor COVID-19 outcomes
New Haven, Conn. — Researchers at the Yale Liver Center found that patients with COVID-19 presented with abnormal liver tests at much higher rates than suggested by earlier studies. They also discovered that higher levels of liver enzymes — proteins released when the liver is damaged — were associated with poorer outcomes for these patients,...
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Scientists develop blood test to help improve liver cancer screening
by National Cancer Institute Scientists have developed a new test that can help identify people who are likely to develop hepatocellular carcinoma (HCC), the most common form of liver cancer. The approach uses a simple blood test to check for the patient’s previous exposure to certain viruses. A study of the new approach was led...
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SLC35B1 as a key modulator of a UDPGA transporter into the endoplasmic reticulum
Researchers from Kanazawa University identify SLC35B1 as the UDP-glucuronic acid transporter into endoplasmic reticulum. This discovery suggests that SLC35B1 is a key modulator of detoxification process of drugs in the human liver. KANAZAWA UNIVERSITY Kanazawa, Japan – One of the main functions of the liver is to detoxify compounds including drugs and toxicants to reduce...
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What to know about melioidosis
Melioidosis is a condition that occurs when someone comes into contact with certain bacteria in infected water or soil. Some medical professionals also call this condition “Whitmore’s disease,” after the pathologist who first described it. Although melioidosis is most common in southeast Asia and northern Australia, several other countries have also reported it, according to...