by University of Missouri-Columbia Despite countless fad diets, both obesity and metabolic diseases continue to plague communities across the U.S. Now, researchers from the University of Missouri believe that the clue to treatment might be related to estrogen—for both men and women. In two separate studies, Vicki Vieira Potter and Jaume Padilla, researchers in the Department of Nutrition and Exercise Physiology,...
Tag: <span>liver disease</span>
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Walking and strength training may decrease the risk of dying from liver disease
DIGESTIVE DISEASE WEEK San Diego, Calif. (May 19, 2019) — Physical activity, including walking and muscle-strengthening activities, were associated with significantly reduced risk of cirrhosis-related death, according to research presented at Digestive Disease Week® (DDW) 2019. Chronic liver disease is increasing, partly due to the obesity epidemic, and currently there are no guidelines for the...
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Discovery of a host mRNA that inhibits immune functions of antiviral protein RIG-I
by Kanazawa University Hepatitis C virus (HCV) is a hepatotropic virus, with about 80 million chronic infections confirmed worldwide. HCV infection leads to the development of chronic hepatitis, cirrhosis, and in some instances, hepatocellular carcinoma. The recent development of highly potent direct-acting antiviral drugs (DAAs), targeting viral proteins, facilitates virus elimination in >90 percent of treated individuals. However,...
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Towards a blood test for early-stage liver disease
Scientists looked for early detection method for non-alcoholic fatty liver disease (NAFLD) Plasma proteins of NAFLD patients were analyzed by mass spectrometry Six proteins were detected in the blood associated with the early stages of NAFLD Protein PIGR identified as candidate biomarker for liver damage tests One in four people in Western and Asian societies...
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Caspase-2 enzyme inhibitor shows promise for ameliorating fatty liver disease
Researchers at University of California San Diego School of Medicine have discovered using mice and human clinical specimens, that caspase-2, a protein-cleaving enzyme, is a critical driver of non-alcoholic steatohepatitis (NASH), a chronic and aggressive liver condition. By identifying caspase-2’s critical role, they believe an inhibitor of this enzyme could provide an effective way to stop...
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Antibody blocks inflammation, protects mice from hardened arteries and liver disease
Researchers at University of California San Diego School of Medicine discovered that they can block inflammation in mice with a naturally occurring antibody that binds oxidized phospholipids (OxPL), molecules on cell surfaces that get modified by inflammation. Even while on a high-fat diet, the antibody protected the mice from arterial plaque formation, hardening of the...
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Antioxidant found in breast milk prevents liver disease, study finds
Antioxidants are believed to prevent some chronic illnesses – such as cardiovascular disease and cancer – due to their ability to protect against cell damage. New research suggests that a common antioxidant may also protect against nonalcoholic fatty liver disease. A new study suggests that an antioxidant commonly found in breast milk could help...