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Drugging the undruggable, improbable new targets for lung cancer therapy
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Drugging the undruggable, improbable new targets for lung cancer therapy

by John Hewitt , Medical Xpress Credit: R. Salgia et. al., Cell Reports Medicine (2021). DOI: 10.1016/j.xcrm.2020.100186 The growth of solid tumors is frequently driven by mutations in key proto-oncogenes. For non-small-cell lung cancers (NSCLC), somatic mutations in the KRAS (Kirsten RAt Sarcoma virus) gene turn it into an oncogene that renders tumors resistant to common chemotherapies...