EXPERIMENTAL BIOLOGY A new study found that non-pungent synthetic analog of capsaicin — the compound that makes chili peppers hot — made small cell lung cancer cells more responsive to treatment. Small cell lung cancer is a very aggressive form of cancer with a low survival rate. Cisplatin-based combination chemotherapy is typically the first-line treatment...
Tag: <span>Lung cancer</span>
Post
Delivering vaccines directly to the lungs can boost immune responses to respiratory infections or lung cancer: study
by Sarah McDonnell, Massachusetts Institute of Technology Antigen peptides (green) from the novel albumin-binding vaccine (amphiphile, right column) were better retained in the lungs and draining lymph nodes of mice than the control vaccine (soluble, left column). Credit: Rakhra et al., Sci. Immunol. 6, eabd8003 (2021) Many viruses infect their hosts through mucosal surfaces such as...
Post
Enzymatic danse macabre of lung cancer
by King Abdullah University of Science and Technology Through international collaborations with Stanford University and the University of Texas in the U.S., KAUST scientists identified the enzyme NSD3 as a main driver of cancer. Credit: KAUST; Anastasia Serin A chromatin-regulating enzyme has been shown by in-depth interdisciplinary investigations to be a key driver of a common...
Post
Missing protein helps small cell lung cancer evade immune defenses
by UT Southwestern Medical Center Small cell lung cancer (SCLC) is a highly metastatic cancer. The liver is one of the common sites of metastases, as seen in this image of mouse liver with metastatic SCLC lesions. SCLC tumors are composed of tightly packed epithelial cells with few immune cells infiltrating inside the tumor. Credit: UT...
Post
Potential combined drug therapy for lung cancer
KANAZAWA UNIVERSITY IMAGE: GRAPHICAL SCHEMA SHOWING THE MECHANISM FOR OVERCOMING INTRINSIC RESISTANCE TO ALK-TKIS OWING TOTP53 MUTATIONS CREDIT: KANAZAWA UNIVERSITY Most lung cancers are of a type called non-small-cell lung carcinoma (NSCLC). This type of cancer is relatively insensitive to chemotherapy, so NSCLC therapies are usually based on drug treatment. Alectinib is a drug commonly...
Post
Researchers uncover a potential treatment for an aggressive form of lung cancer
UT SOUTHWESTERN MEDICAL CENTER IMAGE: THE IMAGE DEPICTS A NON-SMALL CELL LUNG CANCER TUMOR SURROUNDED BY METABOLITES INVOLVED IN THE HEXOSAMINE BIOSYNTHESIS PATHWAY. CREDIT: CREDIT: ELIZABETH LIEU DALLAS – Jan. 5, 2021 – Researchers at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have discovered a new metabolic vulnerability in a highly aggressive form of non-small cell lung cancer...
Post
Low-dose CT for lung cancer screening: benefit outweighs potential harm
INSTITUTE FOR QUALITY AND EFFICIENCY IN HEALTH CARE For heavy (ex-)smokers, lung cancer screening using low-dose computed tomography (low-dose CT, LDCT) offers more benefit than harm: The procedure can save a number of people from dying of lung cancer; for some of them, it might also prolong overall survival. This is the conclusion drawn by...
Post
Three common medications lower risk and mortality for lung cancer
INTERNATIONAL ASSOCIATION FOR THE STUDY OF LUNG CANCER DENVER–Combined use of aspirin, statins, and metformin is associated with decreased lung cancer incidence and mortality, according to a study published in the Journal of Thoracic Oncology (JTO). The JTO is the official journal of the International Association for the Study of Lung Cancer. All three medications are...
Post
New therapy targets breast cancer metastases in brain
Combination therapy reduces tumor size, dramatically improves survival in mice NORTHWESTERN UNIVERSITY CHICAGO — When breast cancer spreads to the brain, the prognosis is grim. Patients only have about six months to live. Women with HER2-positive breast cancer tend to develop brain metastases in up to 55% of cases. Chemotherapy drugs targeting breast cancer cells...
Post
Lung Cancer and Nail Clubbing
By Dr. Sanchari Sinha Dutta, Ph.D. Reviewed by Emily Henderson, B.Sc. Nail clubbing is characterized by specific changes around and under the toe and fingernails that are caused by certain diseases. Lung cancer is the most frequent cause of nail clubbing. What is nail clubbing? Nail clubbing, also called digital clubbing or Hippocratic nail, is...