Research identifies protein responsible for increasing inflammation and oxidative stressPeer-Reviewed Publication ANGLIA RUSKIN UNIVERSITY A new study has identified a protein that nicotine-free vape fluid increases in the lung, causing damage including oxidative stress, inflammation and breakdown of the blood vessels. The research, published in the journal Microvascular Research demonstrates a range of damaging pathways...
Tag: <span>Lung</span>
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Scientists deliver siRNA therapy to lung
by Jim Fessenden, UMass Chan Medical School Fluoresce images of lung tissue after treatment (top, red), show local distribution of chemically modified siRNA and robust gene silencing in the lung. Credit: UMass Chan Medical School Scientists at UMass Chan Medical School have developed a technology to deliver gene therapy directly to lung tissue through intranasal...
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Newly designed molecule could help treat deadly lung condition
by Isabella Backman, Yale University Overview of modifications differentiating second-geneneration miR-29 from first gen MRG-201/Remlarsen. Top, first-gen MRG-201, the parent compound, bottom, MRG-229 (Next generation miR-29 mimic), the second-gen compound. DNA bases: white circles = unmodified base, blue circles = 2’OMe, purple circles = 2’F, linkages: green circles = phosphorodiester linkage, orange circles = phosphorothioate (PS) linkage. NH2 terminus modification: MRG-201/Remlarsen = cholesterol, BiPPB = platelet-derived growth factor beta...
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Disarming the immune system’s lethal lung response
by Nick Wurm, Cold Spring Harbor Laboratory CSHL researchers have found treating mice with a drug candidate that inhibits a protein called PTP1B can prevent deadly lung inflammation in mice. Seen here are 3D images of mouse lungs treated with (left) and without (right) the PTP1B inhibitor drug candidate. The drug candidate prevented a lethal amount...
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Developing a new treatment for lung cancer
by Christina Benjaminsen, Norwegian University of Science and Technology The figure shows a mouse with lung tumours. The intravenous injection of therapeutic mRNA contained in nanoparticles results in the wide distribution of the drug throughout the body. This may lead to side effects because the mRNA also has an effect on healthy cells. As part of...
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New research identifies key set of signals that control mucus production in the lung
BOSTON UNIVERSITY SCHOOL OF MEDICINE (Boston)–Proper lung function relies on the precise balance of specialized epithelial cells (cells that line the surfaces of the body) that coordinate functions to maintain homeostasis. One important lung cell type is the goblet cell, which secretes mucus that helps protect the lining of the bronchus (major air passages of...
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Female breast cancer surpasses lung as the most commonly diagnosed cancer worldwide
AMERICAN CANCER SOCIETY ATLANTA – FEBRUARY 4, 2021 – Cancer ranks as a leading cause of death in every country in the world, and, for the first time, female breast cancer is the most commonly diagnosed cancer, overtaking lung cancer, according to a collaborative report, Global Cancer Statistics 2020, from the American Cancer Society (ACS)...
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Pneumonia recovery reprograms immune cells of the lung
by Boston University School of Medicine A black and white X-ray picture showing a triangular white area on the left side. A circle highlights the area. Credit: James Heilman, MD./Wikipedia Researchers have determined that after lungs recover from infection, alveolar macrophages (immune cells that live in the lungs and help protect the lungs against infection)...
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Stem cell transplants used to grow fully functional lungs in mice
by Columbia University Irving Medical Center Researchers at Columbia University were able to grow fully functional lungs in mouse embryos using transplanted stem cells. The findings suggest that it may be ultimately possible to use the technique to grow human lungs in animals for patients who need transplants and to study new lung treatments. The...
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They Told Her She Had Flu; Years Later, The Real Illness Was Discovered
Diane Bates lay on the floor of her bathroom in the middle of the afternoon – weak, disoriented and afraid that she might die before someone found her. Bates had been battling what she had been told was a bad case of the flu for weeks. She hoped a bath might make her feel better,...
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