Graphical abstract. Credit: Immunity (2024). DOI: 10.1016/j.immuni.2024.09.004 Immune cells called monocytes produce a key inflammatory protein called interleukin-1 beta (IL-1β) through an unconventional pathway in patients with systemic lupus erythematosus, commonly referred to as lupus, according to a new study by Weill Cornell Medicine investigators. The findings, published in Immunity, could lead to new treatments targeting IL-1β to better manage...
Tag: <span>lupus erythematosus</span>
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Non-pharmacological management for systemic lupus erythematosus and systemic sclerosis
by European Alliance of Associations for Rheumatology, EULAR Credit: Unsplash/CC0 Public Domain Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem involvement. Systemic sclerosis (SSc) or scleroderma is another rheumatic autoimmune disease that affects blood vessels, skin, and visceral organs. EULAR has previously published recommendations for the management of these two conditions...
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Dissecting the genetic factors involved in systemic lupus erythematosus development
by University of Tsukuba Credit: Saiful52/Shutterstock Systemic lupus erythematosus (SLE) is a typical autoimmune rheumatic disease. This multifactorial condition results from a combination of multiple genetic and acquired factors. Human leukocyte antigen (HLA), which is responsible for individual differences in immune response, is one of the major genetic factors associated with SLE development. However, its contribution...
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Disturbed gut virome with potent interferonogenic property in systemic lupus erythematosus
SCIENCE CHINA PRESS IMAGE: THE TAXONOMIC PROFILE AND THE INTERFERON-Α-STIMULATORY CAPACITY OF GUT VIRUS-LIKE PARTICLES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS CREDIT: ©SCIENCE CHINA PRESS This study is led by Prof. Xuan Zhang (Beijing Hospital) and Prof. Jun Wang (Chinese Academy of Sciences). Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease that can affect...