by Laurie Fickman, University of Houston Credit: Kindel Media from PexelsNew biomarkers with improved diagnostic performance for early detection of lupus nephritis have been discovered in the University of Houston lab of Chandra Mohan, a pioneer in lupus research. Early identification of renal involvement in lupus and prompt treatment are essential in reducing the pain, suffering...
This review provides a comprehensive summary of the latest advancements in targeted therapies for lupus nephritis, discusses the forthcoming challenges, and proposes strategies to effectively overcome these obstaclesPeer-Reviewed Publication CACTUS COMMUNICATIONS SLE INVOLVES ABNORMAL ACTIVATION OF BOTH INNATE AND ADAPTIVE IMMUNE RESPONSES, LEADING TO SYSTEMIC IMMUNE DYSREGULATION AND RENAL IMPAIRMENT. THE COMPLEMENT SYSTEM’S DYSFUNCTION IMPEDES...
Peer-Reviewed Publication WILEY In a post hoc analysis of the phase 2 NOBILITY trial, researchers found that treatment with obinutuzumab—an antibody that targets a protein expressed on certain immune cells—was superior to placebo for preserving kidney function and preventing flares in patients with lupus nephritis, a kidney condition associated with the autoimmune disease lupus. In...
by Laurie Fickman, University of Houston Antibody pair selection for construction of ALCAM LFA. (A) 57 antibody pairs (eight types of antibodies were tested in all combinations and with each serving as detection Ab-the antibody conjugated onto the nanophosphors and as capture Ab-the antibody immobilized onto the LFA strip) were tested for ALCAM LFA performance,...
