by Wiley Credit: CC0 Public Domain Tyrosine kinases are enzymes that play central roles in signaling by cytokines involved in the pathogenesis of autoimmune diseases, including lupus. A recent phase 2 clinical trial published in Arthritis & Rheumatology has generated promising results for deucravacitinib, an oral inhibitor of tyrosine kinase 2 (TYK2), in patients with active lupus....
HOSPITAL FOR SPECIAL SURGERY After sun exposure, people with systemic lupus erythematosus (SLE) frequently develop skin rashes, which often are accompanied by a flare of their overall disease. This connection between ultraviolet (UV) light and disease flares in lupus is well known, but the way in which UV exposure actually triggers the disease has been...
by Bob Yirka , Medical Xpress Scanning electromicrograph of Staphylococcus aureus bacteria. Credit: NIAID A team of researchers at the Tohoku University Graduate School of Medicine, working with a colleague from Japan’s National Cancer Center, has found that the presence of Staphylococcus aureus on the skin of test mice with a lupus-like disease was found...
Tony Ho Tran Deputy Editor, Innovation & Tech Updated Nov. 03, 2022 2:23 PM ET / Published Nov. 03, 2022 2:00 PM ET Yuichiro Chino via Getty Autoimmune disorders cause the body’s own defense system to attack normal, healthy cells. They can also leave people vulnerable to diseases—resulting in more severe and deadly infections. But...
by Denise Mann An experimental drug that has been shown to treat rashes in people with lupus may also help with lupus-related joint pain. Affecting as many as 1.5 million people in the United States, lupus is an autoimmune disease in which the body’s immune system misfires against its own joints, skin, brain, lungs, kidneys and blood...
by University of Michigan Transcriptional modulation by the LE (Model A: epitope + IFN-γ, versus IFN-γ alone). a Heatmaps showing unsupervised clustering of upregulated (left, yellow) and downregulated (right, purple) DEGs for 65-79*LE, 65-79*SE and 65-79*PE. DEGs were selected based on a > 3-fold change for 65-79*LE. All depicted DEGs had a Padj < 0.05. b Venn diagrams showing comparison of DEGs for 65-79*LE,...
MICHIGAN MEDICINE – UNIVERSITY OF MICHIGAN Researchers at Michigan Medicine have uncovered the molecular mechanism that drives the disease-causing effects of the most common genetic risk factor for lupus, a study suggests. Systemic lupus erythematosus is a common, incurable autoimmune disease that affects millions of individuals worldwide, with a particularly high prevalence among women. A...
A study suggests that researchers at Michigan Medicine have uncovered the molecular mechanism that drives the disease-causing effects of the most common genetic risk factor for lupus. Systemic lupus erythematosus is a common, incurable autoimmune disease affecting millions worldwide, with a particularly high prevalence among women. A genetic variant, called HLA-DRB1*03:01, is the greatest risk factor...
by Hokkaido University When mice that exhibit SLE-like symptoms are subjected to sleep deprivation stress, their neurons exhibit abnormal growth (left). When IL12 and 23 are blocked, the abnormal growth is reversed (right). Credit: Nobuya Abe et al, Annals of the Rheumatic Diseases (2022) Systemic lupus erythematosus (SLE) is an autoimmune disease that affects all the organ...
Published June 1, 2022 Permission granted by Bristol-Myers Squibb Dive Brief: Bristol Myers Squibb’s experimental autoimmune disease drug deucravacitinib helped treat moderate-to-severe lupus in a Phase 2 trial, the company reported Wednesday. Results, which were presented at a medical conference in Denmark, showed two doses of the pill led to significantly higher response rates than did...
