by Theresa Larkin, Alison Tomlin and Laurencia Villalba, The Conversation Credit: Shutterstock The lymphatic system has long been considered mysterious. Unlike blood vessels, lymphatic vessels are not very visible to the naked eye, even during surgery. Because of this, the anatomy and functions of the lymphatic system have historically not been well studied. The fluid in the lymphatic...
Graphical abstract. Credit: Cell (2023). DOI: 10.1016/j.cell.2023.02.021 Cancer treatment routinely involves taking out lymph nodes near the tumor in case they contain metastatic cancer cells. But new findings from a clinical trial by researchers at UC San Francisco and Gladstone Institutes shows that immunotherapy can activate tumor-fighting T cells in nearby lymph nodes. The study, published in...
by Linda Koffmar, The Swedish Research Council Co-expression of fibroblast and adipocyte markers suggest lipomatosis is driven by adipogenic transdifferentiation of medullary fibroblasts. Immunofluorescence staining of lymph nodes (LNs) with lipomatosis. (A) Presence of adipocytes (perilipin, magenta) and fibroblasts (alpha smooth muscle actin; αSMA, green) in medullary cords. Arrowheads indicate adipocytes present in the layer of medullary...
by Torsten Fischer, Helmholtz Association of German Research Centres Researchers can now better understand the system of lymph nodes and their blood vessels. Credit: Paul Schütz When our immune system runs, it sets in motion antibodies, white blood cells and phagocytes. But all the details of how this works are not yet understood—specifically, in the...
by Columbia University Lung lymph nodes from six non-smokers between the ages of 20 and 62. Particles of air pollution darken the lymph nodes and impair immune cells within the nodes. Credit: Donna Farber / Columbia University Irving Medical Center The diminished power of the immune system in older adults is usually blamed on the...
PI3K is a protein that is part of a pathway that regulates cell growth, survival and metabolism — earning it the inscription of master regulator for cancer. However, while a number of PI3K inhibitor drugs have been approved since 2014, the class as a whole has dwindled, as it has been plagued by toxicity issues...
By Michael Irving August 16, 2022 A new mRNA cancer vaccine is designed to target the lymph nodes to induce a stronger immune response Depositphotos Researchers at Tufts University have created a new mRNA vaccine for cancer that’s designed to carry its cargo to the lymph nodes rather than the liver. Tests in mice showed...
Research from the University of Michigan Rogel Cancer Center could provide a new approach to treating an aggressive form of breast cancer. A study led by Duxin Sun, Ph.D., found that targeting the immune microenvironment in lymph nodes and tumors simultaneously led to long-term tumor remission in mice models of metastatic triple-negative breast cancer. Further, using nanoparticles to deliver these...
Cornell researchers have for the first time successfully imaged the entire depth of the lymph nodes in a living mouse using three-photon microscopy. The breakthrough technique’s micrometer clarity and noninvasive nature allowed the team to observe the dynamic interactions of immune cells in real time and in an environment that is notoriously dense and difficult...
by Tohoku University Perfusion defect in the lymph node visualized by contrast-enhanced micro-computed tomography and high-frequency ultrasound (arrows). Credit: Tohoku University If not caught quickly, cancer cells often spread to other organs in a process called metastasis. Lymph nodes (LNs) are the organs with the highest risk of metastasis. Metastasis in the LNs also influences...
