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Aberrant RNA splicing events in acute lymphoblastic leukemia underlies resistance to immunotherapy
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Aberrant RNA splicing events in acute lymphoblastic leukemia underlies resistance to immunotherapy

by Children’s Hospital of Philadelphia A Wright’s stained bone marrow aspirate smear of patient with precursor B-cell acute lymphoblastic leukemia. Credit: VashiDonsk/Wikimedia/CC BY-SA 3.0 Aberrant splicing of messenger RNAs encoding surface antigen CD22 leads to downregulation of this protein in pediatric B-lymphoblastic leukemia (B-ALL), rendering malignant cells resistant to the effects of CD22-directed immunotherapies, according...

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New treatment combination without chemotherapy is effective in PH+ acute lymphoblastic leukemia

SWOG CANCER RESEARCH NETWORK The combination of dasatinib, blinatumomab, and prednisone can be effective in treating older patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) who are not good candidates for intensive chemotherapy treatment. These results from the S1318 clinical trial, led by the SWOG Cancer Research Network, a cancer clinical trials group funded...