WEILL CORNELL MEDICINE DNA mutations are essential to the rapid development of an array of antibody-producing immune cells called B cells that collectively can recognize a vast number of specific targets. But this process can go awry in people with a mutation in a gene called SETD2, leading to a type of aggressive blood cancer,...
Tag: <span>Lymphoma</span>
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NK cells combined with bispecific antibody showed strong response for patients with lymphoma
by University of Texas M. D. Anderson Cancer Center Hodgkin lymphoma, nodular lymphocyte predominant (high-power view) Credit: Gabriel Caponetti, MD./Wikipedia/CC BY-SA 3.0 Researchers from The University of Texas MD Anderson Cancer Center showed that natural killer (NK) cells derived from donated umbilical cord blood, combined with a novel bispecific antibody known as AFM13 that targets...
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Lymphoma cell metabolism may provide new cancer target
by Weill Cornell Medical College Diffuse large B-cell lymphoma. Credit: CoRus13, distributed under a CC BY-SA 4.0 license Aggressive and relatively common lymphomas called diffuse large B cell lymphomas (DLBCLs) have a critical metabolic vulnerability that can be exploited to trick these cancers into starving themselves, according to a study from researchers at Weill Cornell Medicine...
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International collaboration set to investigate new treatment strategy for lymphoma
QUEEN MARY UNIVERSITY OF LONDON An international collaboration involving researchers from Queen Mary University of London, Memorial Sloan Kettering Cancer Center (MSK), New York, and Dana-Farber Cancer Institute, Boston has secured a €1M research grant from Dutch blood cancer charity, Lymph&Co, to investigate a new treatment target for lymphoma. The aim of the project is...
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Clinical feasibility of individualized therapy in leukemia and lymphoma patients
by Johannes Angerer, Medical University of Vienna Figure S1. Sunburst plot showing the classes of drugs tested by scFPM. Drugs can be broadly classified into kinase inhibitors, immunomodulatory drugs, epigenetic modifiers, metabolic modifiers, apoptotic modulators, classical chemotherapeutics and other drugs. Credit: DOI: 10.1158/2159-8290.CD-21-0538 Standard therapy for advanced recurring aggressive, hematological malignancies, such as leukemias and lymphomas,...
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Researchers discover a novel class of drugs that may help treat a deadly type of lymphoma
THE MOUNT SINAI HOSPITAL / MOUNT SINAI SCHOOL OF MEDICINE New York, NY (June 22, 2021) – A new class of drugs that inhibits a “master switch” involved in the vast majority of cases of mantle cell lymphoma (MCL), a fatal subtype of non-Hodgkin’s lymphoma, has been discovered by researchers at Mount Sinai. In a study in Clinical...
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Newly identified gut cells nurture lymph capillaries
by Institute for Basic Science Fingerlike projections that cover the intestinal wall and absorb nutrients in the small intestine.During digestion, hydrophilic nutrients, such as glucose and amino acids, are absorbed by blood capillaries. On the other hand, hydrophobic nutrients, such as lipids, are taken in by specialized lymphatic capillaries called lacteals. The graphics also shows...
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Better vaccines are in our blood
by Harvard University Red blood cells do more than shuttle oxygen from our lungs to our organs: they also help the body fight off infections by capturing pathogens on their surfaces, neutralizing them, and presenting them to immune cells in the spleen and liver. Now, a team of researchers from Harvard’s Wyss Institute for Biologically...
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Improved cancer immunotherapies require radical CAR overhaul
by Johannes Angerer, Medical University of Vienna CAR-T cell therapy is a new and revolutionary weapon against cancer: T cells are isolated from the patient’s blood for genetic modification and then infused back into the patient to attack cancer cells. Researchers from the Medical University of Vienna have now determined why CAR-T cells do not...
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A metabolic enzyme drives lymphoma and is a potential drug target
by Memorial Sloan Kettering Cancer Center Because of how aggressively they divide, cancer cells have an increased demand for building materials and energy. They meet these added demands by altering their metabolism—taking in larger amounts of fuel, for example. Historically, these metabolic changes have been considered a consequence rather than a cause of cancer, and...