September 3, 2024 by Johns Hopkins University School of Medicine In a sea of cancer cells (blue), macrophages (green) are close neighbors to metastatic-initiating cancer cells (magenta). Credit: Won Jin Ho, Johns Hopkins Kimmel Cancer CenterIn a study using human breast cancer cells, scientists say they have potentially identified immune system white blood cells that...
Tag: <span>macrophage</span>
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Cancer stem cells trigger macrophage aging in mouse study
by Hokkaido University (Top) Cancer stem cells produce interleukin-6 (IL-6), which induces senescence in macrophages (Mφ). In turn, these produce arginase-1 and inactivate T cells. As a result, cancer cells are not killed by immune system cells, leading to tumor formation. (Bottom) Non-cancer stem cells do not produce IL-6. Macrophages do not age and T cells...