by Karolinska Institutet Model highlighting epigenetic chromatin remodeling at the Ccl2 locus, encoding the pro-inflammatory chemokine CCL2 (MCP-1), a potential therapeutic target. Credit: Zhiqiang Huang and Rongrong Fan How do cis-regulatory genome elements regulate gene expression, what are the critical components involved, and can we therapeutically target them? By investigating how corepressors modulate enhancers and silencers...
