by Menzies School of Health Research Map of incremental cost-effectiveness ratios (ICERs) in each malaria-endemic municipality for Scenario 1 (tafenoquine for adults, primaquine adherence 66.7%), Scenario 2 (tafenoquine for all, primaquine adherence 66.7%), Scenario 3 (tafenoquine for adults, high primaquine adherence of 90%), and Scenario 4 (tafenoquine for adults, low primaquine adherence of 30%), compared to...
Distributed via the CDC Health Alert NetworkJune 26, 2023, 5:00 PM ET CDCHAN-00494 SummaryThe Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network (HAN) Health Advisory to share information and notify clinicians, public health authorities, and the public about— Identification of locally acquired malaria cases (P. vivax) in two U.S. states...
by Delthia Ricks, Medical Xpress Antibody-mediated NK cell activity in children: (A) Merozoite opsonizing antibodies from Junju adults (n=40) induced a significantly higher proportion of ab-NK cells degranulation compared to Junju children (n=293). Hyperimmune (PHIS) and malaria naive plasma were included as positive and negative controls, respectively. Error bars represent a 95% confidence interval of...
by Carla K. Johnson This 2014 photo made available by the U.S. Centers for Disease Control and Prevention shows a feeding female Anopheles funestus mosquito. The species is a known vector for malaria. The parasitic disease killed more than 620,000 people in 2020 and caused 241 million cases, mainly in children under 5 in Africa....
by University of Bergen a-c: Deterministic sensitivity analysis for Malawi; tornado diagram of community-delivered PDMC and facility-delivered PDMC versus standard of care (1a, 1b), and a comparison of both PDMC strategies (1c). Credit: eClinicalMedicine (2022). DOI: 10.1016/j.eclinm.2022.101669 Young children in sub-Saharan Africa often become severely anemic as consequence of a malaria infection. Treating them requires blood transfusions and...
by Instituto Gulbenkian de Ciência (IGC) Brain vascular endothelial cells (blue) internalize particles released by erythrocytes infected with the malaria parasite (pink and red). Credit: Teresa Pais, 2022 A team of researchers from the Instituto Gulbenkian de Ciência (IGC) revealed that cells of the brain can detect the presence of malaria parasites in the blood,...
One injection of a candidate monoclonal antibody (mAb) known as L9LS was found to be safe and highly protective in U.S. adults exposed to the malaria parasite, according to results from a National Institutes of Health Phase 1 clinical trial published in The New England Journal of Medicine. Additional clinical trials evaluating if L9LS can prevent malaria over six to 12...
by Johns Hopkins University Bloomberg School of Public Health Credit: CC0 Public Domain Blocking a key protein found in Anopheles gambiae mosquitoes—the principal vector for malaria transmission to humans in Africa—could thwart infection with malaria parasites and thus prevent them from transmitting the parasites to humans, according to a study from researchers at the Johns...
by Monash University Alphonse Levaran’s drawings of malaria parasites invading red blood cells in the year 1880, now updated with new research showing that the immune system adapts to protect us from disease. Credit: Artwork created by Dr Erica Tandoori. Monash University’s Biomedicine Discovery Institute researchers have made a vital breakthrough in the understanding of a...
by Walter Reed Army Institute of Research Credit: CC0 Public Domain Scientists from the Walter Reed Army Institute of Research and Naval Medical Research Center partnered with researchers at the University of Pennsylvania and Acuitas Therapeutics to develop a novel vaccine based on mRNA technology that protects against malaria in animal models, publishing their findings in...
