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Study finds tafenoquine is a cost-effective treatment option for malaria
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Study finds tafenoquine is a cost-effective treatment option for malaria

by Menzies School of Health Research Map of incremental cost-effectiveness ratios (ICERs) in each malaria-endemic municipality for Scenario 1 (tafenoquine for adults, primaquine adherence 66.7%), Scenario 2 (tafenoquine for all, primaquine adherence 66.7%), Scenario 3 (tafenoquine for adults, high primaquine adherence of 90%), and Scenario 4 (tafenoquine for adults, low primaquine adherence of 30%), compared to...

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Locally Acquired Malaria Cases Identified in the United States

Distributed via the CDC Health Alert NetworkJune 26, 2023, 5:00 PM ET CDCHAN-00494 SummaryThe Centers for Disease Control and Prevention (CDC) is issuing this Health Alert Network (HAN) Health Advisory to share information and notify clinicians, public health authorities, and the public about— Identification of locally acquired malaria cases (P. vivax) in two U.S. states...

Killing is their job: Two studies analyze natural killer cells as they tackle the worst form of malaria
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Killing is their job: Two studies analyze natural killer cells as they tackle the worst form of malaria

by Delthia Ricks, Medical Xpress Antibody-mediated NK cell activity in children: (A) Merozoite opsonizing antibodies from Junju adults (n=40) induced a significantly higher proportion of ab-NK cells degranulation compared to Junju children (n=293). Hyperimmune (PHIS) and malaria naive plasma were included as positive and negative controls, respectively. Error bars represent a 95% confidence interval of...

Malaria treatment is saving money while saving young lives
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Malaria treatment is saving money while saving young lives

by  University of Bergen a-c: Deterministic sensitivity analysis for Malawi; tornado diagram of community-delivered PDMC and facility-delivered PDMC versus standard of care (1a, 1b), and a comparison of both PDMC strategies (1c). Credit: eClinicalMedicine (2022). DOI: 10.1016/j.eclinm.2022.101669 Young children in sub-Saharan Africa often become severely anemic as consequence of a malaria infection. Treating them requires blood transfusions and...

The brain can detect infection with malaria
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The brain can detect infection with malaria

by Instituto Gulbenkian de Ciência (IGC)  Brain vascular endothelial cells (blue) internalize particles released by erythrocytes infected with the malaria parasite (pink and red). Credit: Teresa Pais, 2022 A team of researchers from the Instituto Gulbenkian de Ciência (IGC) revealed that cells of the brain can detect the presence of malaria parasites in the blood,...

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Monoclonal antibody prevents malaria in U.S. adults

One injection of a candidate monoclonal antibody (mAb) known as L9LS was found to be safe and highly protective in U.S. adults exposed to the malaria parasite, according to results from a National Institutes of Health Phase 1 clinical trial published in The New England Journal of Medicine.  Additional clinical trials evaluating if L9LS can prevent malaria over six to 12...

Scientists identify promising transmission chain-breaker in the fight against malaria
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Scientists identify promising transmission chain-breaker in the fight against malaria

by Johns Hopkins University Bloomberg School of Public Health Credit: CC0 Public Domain Blocking a key protein found in Anopheles gambiae mosquitoes—the principal vector for malaria transmission to humans in Africa—could thwart infection with malaria parasites and thus prevent them from transmitting the parasites to humans, according to a study from researchers at the Johns...

Unconventional T cells promote immunity to malaria
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Unconventional T cells promote immunity to malaria

by  Monash University Alphonse Levaran’s drawings of malaria parasites invading red blood cells in the year 1880, now updated with new research showing that the immune system adapts to protect us from disease. Credit: Artwork created by Dr Erica Tandoori. Monash University’s Biomedicine Discovery Institute researchers have made a vital breakthrough in the understanding of a...

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