by Jeni Bushman, University of Illinois at Urbana-Champaign Biochemistry professor Nash Kalsotra Credit: University of Illinois at Urbana-Champaign Researchers from the University of Illinois have identified a key process coordinating liver maturation and polyploidization, a state in which cells carry more than two sets of chromosomes. Their findings, published in Genes and Development, provide insight into hepatocyte...
Tag: <span>maturation</span>
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An epigenetic barrier sets the timing of human neuronal maturation
Gabriele Ciceri, Arianna Baggiolini, Hyein S. Cho, Meghana Kshirsagar, Silvia Benito-Kwiecinski, Ryan M. Walsh, Kelly A. Aromolaran, Alberto J. Gonzalez-Hernandez, Hermany Munguba, So Yeon Koo, Nan Xu, Kaylin J. Sevilla, Peter A. Goldstein, Joshua Levitz, Christina S. Leslie, Richard P. Koche & Lorenz StuderNature (2024) AbstractThe pace of human brain development is highly protracted compared...
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Maturation instead of cell death: Defective signaling pathways disrupt immune cell development
by University of Freiburg A) UMAP projection of composite healthy donor (HD) samples from CD19+ cells of tonsil (n=7) and spleen (n=7) analyzed by spectral flow cytometry. (B) Identification of primary populations in one representative HD spleen and tonsil. (C) Identification of populations in the naïve B cell gate (IgD+CD38low). (D) Identification of populations within the...