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The New JAK inhibitor Upadacitinib (Rinvoq) Shows Promise for Psoriatic Arthritis

Approved in 2019 for moderate to severe rheumatoid arthritis, the drug may offer an oral alternative to infused or injected biologics. The JAK inhibitor upadacitinib (Rinvoq) became a treatment option in 2019 for people with rheumatoid arthritis(RA) who had not responded well to methotrexate, the disease-modifying anti-rheumatic drug (DMARD) that is the first-line treatment for...

Geochemistry test can identify osteoporosis earlier than current ‘gold-standard’ test
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Geochemistry test can identify osteoporosis earlier than current ‘gold-standard’ test

by Goldschmidt Conference In a novel collaboration, clinicians and geochemists have developed a test that can show the presence of osteoporosis before it has a noticeable clinical effect on bones. The methods are still being refined, but initial results show that it is more sensitive than the standard DXA osteoporosis scans, and can identify the...

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First report of systemic delivery of micro-dystrophin gene therapy in children with DMD

One-year data from the first four patients dosed is published in JAMA Neurology NATIONWIDE CHILDREN’S HOSPITAL Researchers from Nationwide Children’s Hospital have published in JAMA Neurology results from the first four patients treated in the first clinical trial of systemic delivery of micro-dystrophin gene therapy in children with Duchenne muscular dystrophy (DMD) – and initial...

Fruit fly study reveals link between the gut and death by sleep deprivation
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Fruit fly study reveals link between the gut and death by sleep deprivation

by Harvard Medical School The first signs of insufficient sleep are universally familiar. There’s tiredness and fatigue, difficulty concentrating, perhaps irritability or even tired giggles. Far fewer people have experienced the effects of prolonged sleep deprivation, including disorientation, paranoia and hallucinations. Total, prolonged sleep deprivation, however, can be fatal. While it has been reported in...

US regulators approve new type of contraceptive gel
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US regulators approve new type of contraceptive gel

by Linda A. Johnson Phexxi, a contraceptive made by San Diego-based Evofem Bioscience. The Food and Drug Administration on Friday, May 22, 2020 approved the new contraceptive. (Christine Blackburne via AP) U.S. regulators on Friday approved a birth control gel that works in a new way to prevent pregnancy. Phexxi—pronounced FECK’-see—comes in an applicator that...

Smartphone Measures Hemoglobin Levels in Photos of Eyelids
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Smartphone Measures Hemoglobin Levels in Photos of Eyelids

Anemia is properly diagnosed using a blood test that measures hemoglobin, but simply looking behind a patient’s eyelid can be a pretty good alternative if you know how red the tissue is supposed to be. Now, a team at Purdue University has developed a technology that lets a clinician use smartphone pictures of the inner...