by Charles Darwin University Graphical abstract. Credit: Cells (2024). DOI: 10.3390/cells13030268A cannabis extract has shown positive results in slowing down melanoma cell growth and increasing cell death rates, a new in-vitro study finds. Researchers from Charles Darwin University (CDU) and RMIT investigated programmed cell death caused by a specific cannabis extract (cannabinoid PHEC-66) from the cannabis...
by Ruhr-Universitaet-Bochum NEMO is associated with pathological protein aggregates. Credit: Nature Communications (2023). DOI:10.1038/s41467-023-44033-0 Researchers have identified a mechanism that promotes the breakdown of harmful protein deposits. If it malfunctions, it can lead to Parkinson’s disease. NEMO, a protein that is primarily associated with signaling processes in the immune system, prevents the deposition of protein aggregates...
by University of Tsukuba Credit: Cell Reports (2023). DOI: 10.1016/j.celrep.2023.112914 Obesity not only increases the risk of metabolic syndrome-related diseases, such as diabetes, fatty liver, and atherosclerosis, but also remarkably impacts seemingly unrelated conditions, such as cancer, psychiatric disorders, and immune function. To understand this wide range of diseases and develop therapeutic approaches for the...
Peer-Reviewed Publication AARHUS UNIVERSITY IMAGE: “WE HAVE DISCOVERED THAT A PROTEIN CALLED PCSK9, WHICH INFLUENCES THE CHOLESTEROL LEVELS IN THE BLOOD AND INCREASES THE RISK OF CARDIOVASCULAR DISEASES, ALSO HAS COMPLETELY NEW AND UNEXPECTED EFFECTS IN THE KIDNEYS. THIS KNOWLEDGE CAN POTENTIALLY BE USED TO TREAT PATIENTS WHOSE KIDNEYS ARE OVERLOADED AND THEREFORE HAVE AN...
PENN STATE IMAGE: A PENN STATE-LED RESEARCH TEAM FOUND THAT A MOLECULE CALLED MALAT1 HELPS REGULATE THE CELLS THAT LEAD CANCER INVASION. THE TOP ROW SHOWS BLADDER CANCER CELLS WITH MALAT1 EXPRESSION, WHILE THE BOTTOM ROW SHOWS BLADDER CANCER CELLS WITH REDUCED MALAT1 EXPRESSION. IN THE TOP ROW, THE CELLS ARE BEGINNING THEIR MIGRATION AWAY...
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO The protein PKMzeta is known to be associated with long-term memory formation. Neurological disorders such Alzheimer’s disease, as well as depression and aging, correlate with reduced levels of this protein in the brain. Researchers affiliated with institutions in Brazil and the United States have now...
by Cedars-Sinai Medical Center A hairpin loop from a pre-mRNA. Highlighted are the nucleobases (green) and the ribose-phosphate backbone (blue). Note that this is a single strand of RNA that folds back upon itself. Credit: Vossman/ Wikipedia Investigators from the Smidt Heart Institute at Cedars-Sinai have identified how biological pacemaker cells—cells that control your heartbeat—can “fight...
by Oregon Health & Science University Caenorhabditis elegans. Credit: Wikipedia Scientists at Oregon Health & Science University have revealed, for the first time and in near-atomic detail, the structure of the key part of the inner ear responsible for hearing. “This is the last sensory system in which that fundamental molecular machinery has remained unknown,”...
by University of Bonn Immune cells isolated from the lungs of mice with ANCA-associated vasculitis: – macrophages (purple big cells on the left side) in the alveoli contribute to the elimination of bleeding by eating up the red blood cells (reddish very small cells, arrows). Credit: Nina Kessler/IMMEI of the University of Bonn The immune...
In patients with serious and long-term COVID-19, disturbed blood coagulation has often been observed. Now, researchers at LiU have discovered that the body’s immune system can affect the spike protein on the surface of the SARS-CoV-2 virus, leading to the production of a misfolded spike protein called amyloid. The discovery points to a possible connection between...
