INSTITUTE OF CANCER RESEARCH Key protein identified that helps turn pancreatic cancer cells into more aggressive form Pattern of cells in pancreatic tumours follows mathematical law first proposed by Alan Turing Fundamental discovery could pave way for new pancreatic cancer treatments Scientists have shown it is possible to reverse a key process that allows pancreatic...
Tag: <span>mechanism</span>
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Disclosure of the mechanism that regulates the resolution of inflammation
INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB BARCELONA) IMAGE: DURING THE INFLAMMATORY PHASE, INFLAMMATORY MARKERS (IN GREEN) ARE LOCALIZED IN THE MACROPHAGES NUCLEUS (IN BLUE) TO ACTIVATE THE SYNTHESIS OF INFLAMMATORY ARNS. CREDIT: IRB BARCELONA Inflammation is a temporary reaction to infection or injury that is intended to attract cells of the immune system so they...
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Possible discovery of mechanism behind mysterious COVID-19 symptoms
by Karin Söderlund Leifler, Linköping University Picture of amyloid from the SARS-CoV-2 virus’ spike protein, seen using an electron microscope. When the spike protein is mixed with the enzyme neutrophil elastase in test tubes, branched protein fibrils are created, which potentially can cause disturbed blood coagulation in patients with COVID-19. Credit: Sofie Nyström and Per...
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Neuroscientists identify mechanism for long-term memory storage
by Mary Kenyon, University of Iowa Credit: CC0 Public Domain A University of Iowa neuroscience research team has identified a fundamental biochemical mechanism underlying memory storage and has linked this mechanism to cognitive deficits in mouse models of Alzheimer’s disease and related dementias. While working to understand how memories are formed and stored in the...
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Scientists reveal mechanism for colon pain and inflammation
by New York University In normal tissue, PAR2—seen here in fluorescent green—is found on the surface of cells, but in inflamed tissue, it moves from the surface of cells to compartments within cells called endosomes. Credit: Bunnett Lab, NYU Dentistry Researchers at the NYU Pain Research Center have identified a mechanism that underlies inflammation and...
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Key stem cell dormancy mechanism discovered
by University Health Network Credit: CC0 Public Domain Princess Margaret Cancer Centre researchers have made new findings that provide a broader understanding of how dormant hematopoietic stem cells are activated and could pave the way towards therapeutic treatments for a number of cancers. The team has made the discovery by performing a deep mechanistic study of...
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Scientists reveal mechanism behind fecal microbiota transplantation
by Osaka City University Credit: Satoshi Uematsu, Osaka City University In a study published in Gastroenterology—Researchers at Osaka City University and the Institute for Medical Science, The University of Tokyo, in collaboration with Brigham and Women’s Hospital in Boston, report the intestinal bacterial and viral metagenome information from the fecal samples of patients with recurrent Clostridioides difficile...
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Scientists reveal mechanism that causes irritable bowel syndrome
KU LEUVEN IMAGE: ABOUT 20% OF PEOPLE SUFFER FROM IBS. CREDIT: POLINA ZIMMERMAN KU Leuven researchers have identified the biological mechanism that explains why some people experience abdominal pain when they eat certain foods. The finding paves the way for more efficient treatment of irritable bowel syndrome and other food intolerances. The study, carried out in mice...
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Newly discovered mechanism controls cancer cell growth and metabolism
by Karolinska Institutet In a new study published in the journal Cell Death & Differentiation, researchers at Karolinska Institutet have conducted a translational study that identified a new mechanism for controlling the breakdown of glucose in several different cancer forms. The discovery could lead to new therapeutic strategies aimed to reduce cancer growth. A common problem with the current...
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Parkinson’s patient skin samples provide clues to disease mechanism and a possible clinical test
by University of Turku A. The first panel shows the relative levels of protein synthesis in cells from healthy donors compared to those from two classes of Parkinson’s patients; those carrying a gain of function LRRK2-G2019S mutation and sporadic cases, the most common form which is not directly inherited. Protein synthesis was reduced in both groups....