THE PHYSIOLOGICAL SOCIETY New research published today in The Journal of Physiology shows that nitrate improves function in the diaphragm, the muscle involved in coughing and breathing, by improving power. The study done in old mice, if replicated in humans, could provide a strategy for helping elderly people clear the lungs more effectively and avoid...
Tag: <span>mechanism</span>
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Negative side effects of opioids could be coming from users’ own immune systems
by American Chemical Society larger the dose of opioid, the larger the antibody response. “This was surprising,” Kyzer says. “We saw antibody responses in people who were taking large doses for as little as 6 months.” The scientists are now working on isolating the key opioid antigenic intermediates in the body that prompt the generation...
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Dietary control of the healing of injury-induced inflammation
This article by Dr. Barry Sears and colleagues is published in Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2020 BENTHAM SCIENCE PUBLISHERS Injuries induce the initiation of inflammation to control the damage. However, the resolution of the injury-induced inflammation leading to healing is not well characterized. This new article by researchers at the Inflammation Research...
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The behavior of therapeutic antibodies in immunotherapy
by CNRS Human antigen CD20 molecules (blue and pink) expressed on the surface of B cells are recognised by type 1 (green), and type 2 (orange) therapeutic antibodies. Only type 1 antibodies can potently recruit complement C1 component (light brown) to elicit complement pathway. Credit: Nicolas Reyes Since the late 1990s, immunotherapy has been the...
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Virus uses decoy strategy to evade immune system, research reveals
by University of Otago University of Otago researchers have learnt more about how viruses operate and can evade the immune system and are now using their discovery to help learn more about COVID-19. The recent research, led by Dr. Mihnea Bostina and Ph.D. student Sai Velamoor from the Department of Microbiology and Immunology and Otago...
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Easy to overdose on paracetamol if you’re selenium deficient, says research
People low on selenium are at risk of paracetamol overdose, even when they follow dosage recommendations, according to research involving the University of Bath in the UK. UNIVERSITY OF BATH A lack of the mineral selenium in the diet puts people at risk of paracetamol overdose, even when the painkiller is taken at levels claimed...
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Tool could improve success in translating drugs from animal studies to humans
by Kayla Wiles, Purdue University Doug Brubaker, a Purdue assistant professor of biomedical engineering, uses computational and experimental approaches to study host-microbiome interactions in cancers and inflammatory diseases. Credit: Purdue University /John Underwood About 50% of people who take the drug infliximab for inflammatory bowel diseases, such as Crohn’s disease, end up becoming resistant or...
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Identification of a new mechanism in the immune system provides knowledge about diseases
by Aarhus University PaludanDepartment of Biomedicine, Aarhus University Credit: Lars Kruse/Aarhus University An active immune system protects against diseases and infections. An overactive immune system is the body’s worst enemy. One example of this is multiple sclerosis, which is a so-called autoimmune disease, while an overactive immune system also leads to some COVID-19 patients becoming...
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NTU and A*STAR scientists develop new way to deliver more drugs through the skin
NANYANG TECHNOLOGICAL UNIVERSITY A PROTOTYPE TEMPORAL PRESSURE DEVICE DEVELOPED BY THE NTU AND A*STAR SCIENTISTS, WHICH CAN PUT PRESSURE ON THE SKIN, THUS CREATING MICROPORES THAT ALLOWS THE DRUGS TO PASS THROUGH THE… view more CREDIT: NTU SINGAPORE Scientists from Nanyang Technological University, Singapore (NTU Singapore) and the Agency for Science, Technology and Research (A*STAR)...
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Diabetes drugs could be used to treat multiple sclerosis
Multiple sclerosis (MS) is a debilitating demyelinating disease. It happens when the insulating covers of nerve cells in the brain and spinal cord are damaged and signal transmission in the nervous system becomes disrupted. Scientists at the University of Edinburgh found a way how the body could protect itself from the damages of MS. This...