This news or article is intended for readers with certain scientific or professional knowledge in the field. Researchers here provide evidence to indicate that increased expression of CD47 in aged blood vessels impairs a range of functions, from maintenance of these tissues to the generation of new blood vessels. The latter point is interesting given...
Tag: <span>mechanism</span>
Phosphoprotein biomarkers to guide cancer therapy are identified
by University of Alabama at Birmingham Precision medicine in cancer treatment uses genetic changes in the cancer cells to select the best therapies for individual patients. Now researchers led by James Bibb, Ph.D., professor of surgery at the University of Alabama at Birmingham, suggest using a broader lens of post-translational modification analysis to identify new...
Headline news: Botox injections don’t just banish your wrinkles – they could also help to treat depression, study suggests
Botox is a muscle-relaxing toxin used cosmetically and for other purposes Researchers mined a US database of side-effects experienced from medications Patients given Botox were compared with those using alternative treatments The team found that the former were 40–88% less likely to report depression Further tests will be needed to confirm if and how Botox...
L-type calcium channel blockers may contribute to heart failure, study finds
by Sara Lajeunesse, Pennsylvania State University L-type calcium channel blockers (LCCBs)—the most widely used drugs for treating hypertension—may harm the heart as much as help it, according to a new study. The research team, led by Penn State, found that in rats and human cells in vitro, LCCBs cause changes in blood vessels—known as vascular...
Different from a computer: Why the brain never processes the same input in the same way
MAX PLANCK INSTITUTE FOR HUMAN COGNITIVE AND BRAIN SCIENCES HOW STRONGLY THE CORTEX IS EXCITABLE BY A STIMULUS (LIGHTNING SYMBOL) IS NOT LEFT TO CHANCE. RATHER, THE CHANGE BETWEEN LOWER AND STRONGER EXCITABILITY FOLLOWS A CERTAIN TEMPORAL PATTERN (VIOLET… view more CREDIT: STEPHANI/ MPI CBS Rustling leaves, light rain at the window, a quietly ticking...
Brain network mechanism causing spatial memory impairment revealed
by University of California, Irvine New study, led by UCI School of Medicine’s Kei Igarashi, PhD, found that remapping of place cells, a brain circuit function to discriminate distinct environments, was disrupted in Alzheimer’s disease mice. Credit: UCI School of Medicine July 21, 2020—Patients with Alzheimer’s disease frequently suffer from spatial memory loss, such as...
Host cell fusion in bacteria infection alarms immune system, causing host cell destruction
NATIONAL UNIVERSITY OF SINGAPORE, YONG LOO LIN SCHOOL OF MEDICINE A GIANT CELL RESULTING FROM BURKHOLDERIA INFECTION UNDERGOING ABORTIVE CELL DIVISION. PART 1: THE GENETIC MATERIAL IN THE GIANT CELL IS HIGHLY CONDENSED, SIMILAR TO WHAT HAPPENS DURING NORMAL CELL… view more CREDIT: DR GAN YUNN HWEN Burkholderia pseudomallei is a bacterium in the soil...
Scientists found that the lack of stress hormone contributes to aging
For hundreds and hundreds of years people have tried to stop the aging process. However, their efforts have never yielded any positive results – there is no youth elixir. Even with the latest scientific advancement we cannot stop the damage that time does on our bodies. But now scientists from Saarland University have figured out...
CRISPR Gene Editing in Human Embryos Wreaks Chromosome Mayhem
By Heidi Ledford, Nature magazine on June 25, 2020 A suite of experiments that use the gene-editing tool CRISPR–Cas9 to modify human embryos have revealed how the process can make large, unwanted changes to the genome at or near the target site. The studies were published this month on the preprint server bioRxiv, and have...
Re-purposed drugs could reverse blood vessel damage in diabetes
by University of Leeds The blood flow in the surface blood vessels of a mouse that was not treated with M-3. Drugs that were developed to treat Alzheimer’s Disease could be re-purposed to prevent—or even reverse—the damage done to the blood vessels in people who are obese or suffer from type 2 diabetes, according to...