Immunotherapies use the immune system to fight cancer. But cancers like melanoma have found ways to turn off the immune system, allowing them to resist treatments and often leading to recurrence. Now University of Colorado Cancer Center clinical trial results published today in the journal International Immunopharmacology describe a promising strategy to remove one of melanoma’s most...
Tag: <span>MELANOMA</span>
Post
Drug combination targeting HSP90 and BRAF is safe and effective in advanced melanoma
XL888 Plus vemurafenib results in manageable toxicity and durable responses in advanced and metastatic melanoma patients TAMPA, Fla. – Patients with advanced or metastatic melanoma have been able to live longer cancer-free lives because of several new therapies approved over the last decade, such as BRAF and MEK inhibitors. However, despite the success of these...
Post
Cancer immunotherapy uses melanin against melanoma
Researchers have developed a melanin-enhanced cancer immunotherapy technique that can also serve as a vaccine, based on early experiments done in a mouse model. The technique is applied via a transdermal patch (shown here) and is made more …more Researchers have developed a melanin-enhanced cancer immunotherapy technique that can also serve as a vaccine, based...
Post
Lung cancer driver ALK-fusion found in melanoma
Melanomas caused by sun exposure have been matched with targeted treatments and immunotherapies, in many cases dramatically extending patients’ lives. However, there are other kinds of melanoma not related to sun exposure and because they are caused by different genetic changes, they are not susceptible to the same targeted treatments. This often leaves patients...
Post
Researchers look to protect ‘self-reactive’ immune cells so they can fight melanoma
CHAPEL HILL — Researchers at the University of North Carolina Lineberger Comprehensive Cancer Center are using what they know about a rare, inherited autoimmune disease to turn the body’s defenses against melanoma. In JCI Insight, researchers report on a potential new way to fight melanoma by blocking one of the immune system’s checks and balances. Combining...
Post
Australian researchers say they can stop melanoma spreading
Melanoma in skin biopsy with H&E stain — this case may represent superficial spreading melanoma. Researchers say a combination of new treatments can stop the world’s deadliest form of skin cancer—melanoma—in its tracks and halt its spread to other organs. Results from two international drug trials conducted by the Sydney-based Melanoma Institute Australia have proved successful...
Post
Breaking the genetic resistance of lung cancer and melanoma
Researchers from Monash University and the Memorial Sloan Kettering Cancer Center (MSKCC, New York) have discovered why some cancers – particularly lung cancer and melanoma – are able to quickly develop deadly resistance to targeted therapies. Dr Luciano Martelotto, from the Monash University Faculty of Medicine, and his collaborators Dr Piro Lito and Yaohua Xue...
Post
People with Parkinson’s should be monitored for melanoma, study finds
People with the movement disorder Parkinson’s disease have a much higher risk of the skin cancer melanoma, and vice versa, a Mayo Clinic study finds. While further research is needed into the connection, physicians treating one disease should be vigilant for signs of the other and counsel those patients about risk, the authors say. The...
Post
Delaying lymph node biopsy after melanoma diagnosis does not affect survival rates
Postponing lymph node biopsy more than 30 days after melanoma diagnosis doesn’t adversely impact long-term clinical outcomes, according to new study findings published online as an “article in press” on the Journal of the American College of Surgeons website ahead of print publication. Every year, about 87,000 people are diagnosed with melanoma, according to the American Cancer Society....
Post
Study: Common surgical treatment for melanoma does not improve patients’ overall survival
Melanoma in skin biopsy with H&E stain — this case may represent superficial spreading melanoma. Patients who receive the standard surgical treatment for melanoma that has spread to one or more key lymph nodes do not live longer, a major new study shows. The study, published today in The New England Journal of Medicine, found...