Treatment with a combination of ipilimumab (Yervoy) and Coxsackievirus A21 (CVA21; Cavatak) led to durable responses in a number of patients with advanced melanoma, including some whose melanoma had progressed despite prior treatment with an immune checkpoint inhibitor, and fewer than anticipated adverse events, according to results from a phase Ib clinical trial presented here...
Tag: <span>MELANOMA</span>
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Absent tumor-suppressors allow melanoma to thwart immunotherapy
Researchers identified a set of genetic changes that predict whether melanoma patients will respond to checkpoint inhibitor therapies. It’s what’s missing in the tumor genome, not what’s mutated, that thwarts treatment of metastatic melanoma with immune checkpoint blockade drugs, researchers at The University of Texas MD Anderson Cancer Center report in Science Translational Medicine. Whole...
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Anti-aging gene identified as a promising therapeutic target for older melanoma patients
Pharmacologic activation of anti-aging gene with anti-diabetic drug could be used as adjuvant therapy for older melanoma patients who have developed resistance to targeted therapy PHILADELPHIA — (Feb. 23, 2017) — Scientists at The Wistar Institute have shown that an anti-diabetic drug can inhibit the growth of melanoma in older patients by activating an anti-aging...
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Patient self checks are critical to avoid potentially deadly melanoma recurrence
New study finds that recurrent melanomas are more likely to be found by patients as opposed to imaging Recurrences of early stage (stage II) melanoma are more often detected by patients and their physicians than by routine imaging tests, according to study results published online as an “article in press” on the Journal of the American...
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PROMISING NEW DRUG STOPS SPREAD OF MELANOMA BY 90 PERCENT
Michigan State University researchers have discovered that a chemical compound, and potential new drug, reduces the spread of melanoma cells by up to 90 percent. The man-made, small-molecule drug compound goes after a gene’s ability to produce RNA molecules and certain proteins in melanoma tumors. This gene activity, or transcription process, causes the disease to...