by Netherlands Cancer Institute Preparing tumor-infiltrating lymphocyte therapy for melanoma patients in the lab. Credit: NKI A patient’s own immune cells, multiplied into an army of billions of immune cells in a lab, can be used as a living medicine against metastatic melanoma, an aggressive form of skin cancer, as the TIL trial has shown....
by Duke University Medical Center Schematic of the tumor-intrinsic NLRP3-HSP70 signaling axis and its role in supporting metastatic progression in the lung in response to anti-PD-1 immunotherapy. Credit: B. Theivanthiran, et al., Science Translational Medicine (2022) Duke Cancer Institute researchers have identified potential biomarkers that predict the likelihood for checkpoint inhibitor drugs to backfire, driving hyper-progression of melanoma...
by University of Pittsburgh Human chromosomes (gray) capped by telomeres (white). Credit: PD-NASA; PD-USGOV-NASA Scientists at the University of Pittsburgh School of Medicine have discovered the missing puzzle piece in the mystery of how melanoma tumors control their mortality. In a paper published in Science this week, Jonathan Alder, Ph.D. and his team describe how they discovered...
UNIVERSITY OF BRISTOL IMAGE: ILLUSTRATION SHOWING HOW MINIATURE ARTIFICIAL PROTOCELLS LOADED WITH ANTI-MICRORNA-223 CARGO CAN REPROGRAM CANCER-ASSOCIATED MACROPHAGES IN LARVAL AND ADULT ZEBRAFISH LEADING THEM TO BE MORE PRO-INFLAMMATORY AND THUS ABLE TO DRIVE MELANOMA SHRINKAGE CREDIT: PACO LOPEZ CUEVAS A new way of reprogramming our immune cells to shrink or kill off cancer cells...
By CAITLIN TILLEY, HEALTH REPORTER FOR DAILYMAIL.COM PUBLISHED: 11:05 EDT, 13 October 2022 | UPDATED: 12:49 EDT, 13 October 2022 Pharma giants Merck and Moderna have teamed up to develop a cancer vaccine that is based on the same tech used in Covid shots. The new shot — designed for people with high-risk melanoma — is in the second of three trials...
by Jeff Hansen, University of Alabama at Birmingham Constitutive activation of JAK1/2 in IFNγR1KO melanoma cells. a Identification of a JAK1/2-centric network of activated protein tyrosine kinases in IFNγR1KO cells by kinomic analysis. Input nodes (kinases) with large blue circles around them and smaller red circles on the top right corner indicate increased activity in IFNγR1KO cells. Arrowheads denote...
by European Society for Medical Oncology Lead author Professor John Haanen. Credit: European Society for Medical Oncology A novel treatment strategy with personalized cell therapy significantly improves progression-free survival compared to standard immunotherapy in patients with advanced melanoma, according to ground-breaking results reported at the ESMO Congress 2022 from the phase 3 M14TIL trial. “This study...
by American Society for Bone and Mineral Research Credit: CC0 Public Domain The use of broad-spectrum antibiotics in mice with malignant melanoma, an aggressive form of skin cancer, accelerated their metastatic bone growth, likely because the drugs depleted the mice’s intestinal flora and weakened their immune response, according to a new study by researchers at...
by Hunter Medical Research Institute Tumor response, PFS, and OS. A, Spider plot of tumor burden change of target lesions in reference to the baseline tumor burden in 18 patients with measurable tumor burden. RECIST/iRECIST, biopsies, and translational bloods were collected at week 9 after azacitidine/carboplatin and week 22 after six cycles of avelumab (indicated...
by Perelman School of Medicine at the University of Pennsylvania Histologic characterization of representative orthotopic skin and resulting tumors, including MC and proliferation markers MITF (red), Ki67 (dark brown, nuclear)/MART (red), and Fontana Masson (melanin, dark brown). Images taken at ×20 magnification. Scale bar, 100 μm. a.u., arbitrary units. Credit: Science Advances (2022). DOI: 10.1126/sciadv.abn4007 People with...
