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Research uncovers Tle3 protein’s role in enhancing memory T cells
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Research uncovers Tle3 protein’s role in enhancing memory T cells

by Hackensack Meridian Health Deletion of Tle3 promotes the formation of TCM cells as manifested at the single-cell level. Credit: Nature Immunology (2024). DOI: 10.1038/s41590-023-01720-wThe Xue Lab at the Hackensack Meridian Center for Discovery and Innovation (CDI) has made another breakthrough in better understanding and potentially modulating the immune system to fight diseases. The insights...

Intricacies of tissue memory T cells could be the future of immunotherapies and vaccines
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Intricacies of tissue memory T cells could be the future of immunotherapies and vaccines

by Doherty Institute for Infection and Immunity  Credit: CC0 Public Domain In a significant step forward in understanding the crucial role tissue-resident memory T (TRM) cells play in the immune system, researchers have for the first time described how the cells behave in different tissues around the body. This discovery adds to the growing knowledge base around...

Researchers map metabolic signaling machinery for producing memory T cells
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Researchers map metabolic signaling machinery for producing memory T cells

ST. JUDE CHILDREN’S RESEARCH HOSPITAL IMAGE: From left: Hongbo Chi, Ph.D., Hongling Huang, Ph.D., and PeiPei Zhou, Ph.D., all of St. Jude Immunology, have mapped the previously unknown biological machinery by which the immune system generates T cells that kill bacteria, viruses and tumor cells. CREDIT: ST. JUDE CHILDREN’S RESEARCH HOSPITAL Immunologists at St. Jude Children’s Research Hospital have mapped the...