by Hong Kong Polytechnic University 3D molecular models of ABarginase, albumin and FcRn receptor on a cell surface. Credit: Hong Kong Polytechnic University Researchers from The Hong Kong Polytechnic University (PolyU) and The Chinese University of Hong Kong (CUHK) have jointly made a groundbreaking drug discovery in treating multiple metabolic diseases related to obesity and insulin...
by Stephanie McPherson, Broad Institute of MIT and Harvard Human pancreatic beta cells show increased membrane rigidity (indicated in red) when exposed to erucic acid, a toxic monounsaturated fatty acid. Credit: Ranjan Devkota and Juliana Coraor Fried Researchers have developed a technology, FALCON, to analyze the effects of free fatty acids in any cell type, and found...
by Sharita Forrest, University of Illinois at Urbana-Champaign Graphical abstract. Credit: Antioxidants (2022). DOI: 10.3390/antiox12010020 A protein in soybeans blocks the production of a liver enzyme involved in the metabolism of triglycerides and low-density lipoprotein, scientists found in a recent study. Consuming soy flour rich in the protein B-conglycinin has the potential to reduce LDL cholesterol levels...
by Joslin Diabetes Center Credit: Unsplash/CC0 Public Domain More than 40 percent of American adults have obesity, a complex condition that can increase the risk of diabetes, cardiovascular disease and certain cancers. One mechanism by which obesity can lead to other health problems is by causing low-grade chronic inflammation, the accumulation of immune cells in...
By Rich Haridy February 14, 2022 A newly discovered compound heightens the expression of a protein that helps regulate insulin secretion from the pancreas Depositphotos A new preclinical study has demonstrated how an experimental drug can treat type 2 diabetes by increasing the expression of a recently discovered protein found to influence insulin signaling in...
Scientists spur advances in fatty liver disease therapy by modifying an existing neurological drug. Nonalcoholic fatty liver disease (NAFLD) severely impairs the quality of life in patients and often leads to various liver complications. Recently, scientists at Gwangju Institute of Science and Technology designed a novel compound that can potentially treat NAFLD by targeting peripheral...
Scientific team found a new metabolism regulation system for the brown adipose tissue using the kallikrein-kinin hormonal system, so far related to the physiology of the renal and cardiovascular system and inflammation and pain processes. This molecular auto-control system of lipidic metabolism, so far unknown, could help prevent the damaging effects derived from an excessive...
by Yale University Many health problems in the developed world stem from the disruption of a delicate metabolic balance between glucose production and energy utilization in the liver. Now Yale scientists report March 4 in the journal Nature that they have discovered the molecular mechanisms that trigger metabolic imbalance between these two distinct but linked...
