by Johns Hopkins University School of Medicine Photograph from a Johns Hopkins Medicine study showing regenerated junctions between peripheral nerves and their muscle fibers in mice. By modifying white blood cells known as macrophages, Johns Hopkins Medicine researchers were able to achieve complete recovery from injury to the nerves. Credit: Mithilesh Kumar Jha, Johns Hopkins Medicine Peripheral nerves—the...
by Flinders University (A) Two distinct AR siRNAs (siAR (1) and siAR (2); 12.5 nM) reduce the expression of 6PGD at the protein level in LNCaP cells. Cells were transfected with 12.5 nM of each siRNA; after 48 h, proteins were extracted and assessed by Western blotting. (B) siAR (2) reduces the expression of 6PGD mRNA...
by Duke University School of Nursing Credit: CC0 Public Domain Most of us remember a time when we could eat anything we wanted and not gain weight. But a new study suggests your metabolism—the rate at which you burn calories—actually peaks much earlier in life, and starts its inevitable decline later than you might guess. The...
New research examines the effects of different types of screen light on sleep. Cavan Images/Getty Images Researchers have shown that exposure to certain types of light before sleep can negatively affect health. In the present study, the scientists wanted to see what effect two different types of light might have on a person’s metabolism during...
by Perelman School of Medicine at the University of Pennsylvania Credit: CC0 Public Domain It has been known for some time that the thyroid gland is a strong regulator of the body’s metabolism, making it key to many health conditions. But the molecular details of how thyroid hormone acts on cells in the body have never...
by Memorial Sloan Kettering Cancer Center Killer T cells surround a cancer cell. Credit: NIH The year 2021 marks the 100th anniversary of a fundamental discovery that’s taught in every biochemistry textbook. In 1921, German physician Otto Warburg observed that cancer cells harvest energy from glucose sugar in a strangely inefficient manner: rather than “burn” it...
by BIH at Charité Influence of genetic variants on metabolite concentration: the higher the line, the greater the statistical probability that the genetic variants actually have an influence. Colors indicate the biochemical classes of the molecules. Credit: BIH/Maik Pietzner The human organism requires a variety of small molecules, such as sugars or fats, in order...
by University of California – San Diego Credit: CC0 Public Domain Researchers at University of California San Diego School of Medicine, in collaboration with Dutch scientists, have found that certain metabolites—small molecules produced by the process of metabolism—may be predictive indicators for persons at risk for recurrent major depressive disorder. The findings were published in the January...
by The Ohio State University Researchers at The Ohio State University Wexner Medical Center conducted a study expecting to confirm how artificial sweeteners contribute to glucose intolerance, but surprisingly learned that the sweeteners have no adverse effects on healthy adults and do not change metabolic profiles or lead to diabetes. Credit: The Ohio State University Wexner Medical...
by The Wistar Institute Ovarian cancer cells. Credit: The Wistar Institute Mutations that inactivate the ARID1A gene in ovarian cancer increase utilization of the glutamine amino acid making cancer cells dependent on glutamine metabolism, according to a study by The Wistar Institute published online in Nature Cancer. Researchers also showed that pharmacologic inhibition of glutamine metabolism may represent an...
