Tag: <span>metabolite</span>

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Metabolite in urine predicts diabetic kidney failure 5–10 years early: Oral therapeutic drug shows promise in mice
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Metabolite in urine predicts diabetic kidney failure 5–10 years early: Oral therapeutic drug shows promise in mice

by University of Texas Health Science Center at San Antonio Credit: Pixabay/CC0 Public DomainUrine levels of adenine, a metabolite produced in the kidney, are predictive and a causative biomarker of looming progressive kidney failure in patients with diabetes, a finding that could lead to earlier diagnosis and intervention, researchers from The University of Texas Health...

Drug discovery method identifies naturally occurring metabolite that converts ‘bad’ fat to ‘good’ fat
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Drug discovery method identifies naturally occurring metabolite that converts ‘bad’ fat to ‘good’ fat

SCRIPPS RESEARCH INSTITUTE IMAGE: ZAFIRLUKAST INDUCES THE PRODUCTION OF BROWN ADIPOCYTE TISSUE. FOR PREADIPOCYTES TREATED WITH ZAFIRLUKAST (RIGHT IMAGE), BROWN ADIPOCYTES (SHOWN IN RED) WERE MUCH MORE PREVALENT THAN PREADIPOCYTES GROWN WITH THE DMSO CONTROL (LEFT IMAGE). CREDIT: SCRIPPS RESEARCH AND CALIBR LA JOLLA, CA— “Metabolism” describes the body’s chemical changes that create the necessary materials...

Researchers discover a new diet-associated gut-microbe metabolite linked to cardiovascular disease
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Researchers discover a new diet-associated gut-microbe metabolite linked to cardiovascular disease

by Cleveland Clinic Cleveland Clinic researchers have identified a gut microbe generated byproduct—phenylacetylglutamine (PAG) – that is linked to development of cardiovascular disease, including heart attack, stroke and death. The study was published in Cell today. Cleveland Clinic researchers, led by Stanley Hazen, MD, PhD, have identified a gut microbe generated byproduct – phenylacetylglutamine (PAG)...

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Key mechanism in insulin release by cholesterol metabolite found

LUND UNIVERSITY Insulin which is released by pancreatic beta-cells is the main regulator of blood sugar. Previous and current studies by a research group at Lund University in Sweden have identified around hundred different receptors on the surface of the beta-cells, with a diverse functional impact on the beta-cells. Now researchers at Lund University in...