by Cleveland Clinic Credit: CC0 Public Domain A Cleveland Clinic research team has published an “atlas” of metabolites associated with cardiovascular disease in the European Heart Journal. The novel findings provide key details about the routes and potential branching paths taken by bacteria and metabolic by-products, metabolites. The study mapped out the multiple by-products of bacteria-processing amino acids associated with cardiovascular disease and then...
by Uppsala University The study is based on analyses of both fecal and blood samples from 8,583 participants in the Swedish CArdioPulmonary bioImage Study (SCAPIS). Credit: Petra Olsson There are strong links between bacteria living in the gut and the levels of small molecules in the blood known as metabolites. This is the finding of...
by Children’s Hospital Boston This schematic illustrates the growth or “fitness” of various Bacteroides species exposed to different sugars, alone and with the bacterial metabolite butyrate. The strains in green on the right are the most fit and best able to tolerate butyrate, while those shown in red die off. The fitness profiles vary from...
UNIVERSITY OF TSUKUBA Tsukuba, Japan – Keeping everything running smoothly inside the human body is a tricky business that involves a multitude of checks and balances to make sure that an exquisite equilibrium is maintained. Now, researchers from Japan have identified a single protein that helps balance both sugar and fat levels in the liver...
Rapid, inexpensive and non-invasive technique can track malignant melanoma progression or treatment response DE GRUYTER What if you could simply provide a urine sample rather than undergo a painful surgical procedure to find out if your cancer was responding to treatment? It may seem too good to be true, but researchers at Pavol Jozef Šafárik...
Toward an era where aging can be controlled KUMAMOTO UNIVERSITY THE HUMAN BODY AND THE CELLS THAT MAKE IT UP HAVE A “PROGRAM ” FOR AGING. IT IS THOUGHT THAT THERE IS AN ACCUMULATION OF SENESCENT CELLS IN TISSUES AND ORGANS… view more CREDIT: PROFESSOR MITSUYOSHI NAKAO Researchers from Kumamoto University in Japan have used...
Context and Significance Respiratory viral diseases, such as seasonal influenza or COVID-19, are deadly scourges on society. Immunometabolic therapies may be important tools to reduce the burden of death and long-term disability caused by pandemic viruses. Here, we describe the biological effects of ketone bodies, natural metabolites produced during fasting or carbohydrate restriction, that maintain...
In recent years academic interest has grown in the study of the gut microbiome. Researchers are making inroads into understanding the considerable influence of these microbial populations over the progression of health and aging. The gut microbiome may be as influential as physical activity in these matters. The balance of microbial populations shifts unfavorably over...
Scientists have completed large-scale tests on a new type of five-minute urine test that measures the health of a person’s diet, and produces an individual’s unique urine ‘fingerprint’. Scientists have completed large-scale tests on a new type of five-minute urine test that measures the health of a person’s diet, and produces an individual’s unique urine...
by Yale University Our cells have several ways to repair DNA that breaks when the cells divide. However, genetic mutations can disable these DNA repair mechanisms, destabilize the cells, and trigger cancer. In a paper published today in the journal Nature, Yale Cancer Center (YCC) scientists have identified mutations in metabolite-producing genes as a disruption...
