by German Cancer Research Center Credit: Unsplash/CC0 Public DomainScientists from the German Cancer Research Center (DKFZ) and Heidelberg University have investigated in mice how spreading tumor cells behave at the site of metastasis. Some tumor cells immediately start to form metastases. Others leave the blood vessel and may then enter a long period of dormancy. What...
Tag: <span>metastasis</span>
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New drug candidate may prevent metastasis
by Eric Eraso, University of Central Florida Credit: Pixabay/CC0 Public DomainA UCF College of Medicine researcher is developing a new treatment that could slow or even stop cancer cells from spreading. Dr. Otto Phanstiel, a medicinal chemist, has created a compound that literally stops cells from moving and is working with the Mayo Clinic to optimize...
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First-of-its-kind cancer drug targets mechanism that causes metastasis
By Paul McClure August 03, 2023 Researchers have developed an monoclonal antibody drug that targets the process that causes cancer cells to spread in the body Depositphotos Metastatic cancer accounts for up to 90% of all cancer deaths in the US annually. But with researchers developing a first-of-its-kind drug that inhibits the process by which cancer cells...
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Researchers discover how melanoma changes its environment to support metastasis
by Tel-Aviv University Credit: Pixabay/CC0 Public Domain A new study conducted at Tel Aviv University and the Sheba Medical Center reveals how melanoma cancer cells affect their close environment to support their needs—by forming new lymph vessels in the dermis in order to go deeper into the skin and spread through the body. The researchers believe...
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Scientists identify cellular signaling pathway as key player in metastasis
by Memorial Sloan Kettering Cancer Center A quiescent cluster of lung adenocarcinoma tumor cells from a patient’s lymph node shows low STING expression. Credit: Massagué Lab, Sloan Kettering Institute. A team of scientists at the Sloan Kettering Institute have identified the STING cellular signaling pathway as a key player in keeping dormant cancer cells from...
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The molecules behind metastasis
by Greta Friar, Whitehead Institute for Biomedical Research Breast cancer stem cells (red) that have reached the lung begin to divide into clusters that could become metastatic tumors. Credit: Arthur Lambert Many cancer cells never leave their original tumors. Some cancer cells evolve the ability to migrate to other tissues, but once there cannot manage...
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Stopping the spread: Targeting tumor metastasis
TOKYO MEDICAL AND DENTAL UNIVERSITY IMAGE: TAKAHASHI ET AL. SHOW THAT TGF-Β GENERATES A POPULATION OF CANCER CELLS UNDER CELL CYCLE ARREST IN G1 PHASE WITH HIGH MOTILITY BY INDUCING UNIQUE SLUG/HMGA2-INDEPENDENT EPITHELIAL-MESENCHYMAL TRANSITION (EMT). THIS LEADS TO TUMOR PROGRESSION AND POOR PROGNOSIS FOR PATIENTS WITH HEAD AND NECK CANCER. CREDIT: DEPARTMENT OF BIOCHEMISTRY, TMDU...
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Cambridge cancer breakthrough may prompt rethink of metastasis
By Michael Irving October 02, 2022 A new study could recontextualize metastasis in cancer Deposit photos Cancer’s ability to spread through the body is one of its most devastating tricks. Scientists at Cambridge have now identified a protein that plays a key role in metastasis, which not only hints at a new potential treatment but...
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Cancer cells adopt hitherto unknown state to facilitate metastasis
by Susann Huster, Leipzig University Credit: Pixabay/CC0 Public Domain The ancient Egyptians, as described in the Ebers Papyrus, already knew that palpation—feeling for hardened lumps—can help diagnose breast cancer. Palpation is still an important element in early screening for breast cancer. On the other hand, measurements on individual cancer cells show that they are softer...
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A common mechanism for cancer metastasis and atherosclerosis
by Hokkaido University Oxidized-LDL accumulates (left column) in malignant tumors (bottom) much more than in non-malignant ones (top). This attracts neutrophils (right column, red) to malignant tumors (bottom), but not to non-malignant ones. Credit: Takuya Tsumita, et al. International Journal of Cancer. May 24, 2022 A key molecule for cancer metastasis has been identified as a molecule...