by University of Barcelona The study identifies the cytokine GDF15, a protein whose expression increases in response to cellular stress, as a key factor for the metformin drug to show antidiabetic effects. Credit: Pharmacological Research (2022). DOI: 10.1016/j.phrs.2022.106578 Metformin, the most prescribed drug for treating diabetes mellitus, known as type 2 diabetes, requires the presence of the...
UNIVERSITY OF MINNESOTA MEDICAL SCHOOL Published in the New England Journal of Medicine, researchers — led by the University of Minnesota Medical School and School of Public Health — have found that metformin, a commonly prescribed diabetes medication, lowers the odds of emergency department visits, hospitalizations, or death due to COVID-19 by over 40 percent; and...
Marlene Busko, for Medscape July 28, 2022 The study covered in this summary was published on medRxiv as a preprint and has not yet been peer reviewed. Key Takeaways In an observational study of more than 112,000 US residents aged 50 years or older with type 2 diabetes, new users of metformin had about a 20% lower rate of incident...
THE ENDOCRINE SOCIETY Patients with type 2 diabetes have an increased risk for fractures, despite their normal-to-high bone mineral density, according to research being presented Saturday, June 11 at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga. “Patients using insulin or sulfonylurea are at a high risk of fractures compared to metformin-only users,...
Yale researchers have further elucidated the mechanism of metformin, a widely used type 2 diabetes medication that, despite its long history of being safe and effective, works in a way that has remained elusive to scientists. On March 1, Gerald Shulman, MD, PhD, George R. Cowgill Professor of Medicine (Endocrinology) and professor of cellular and molecular physiology, published his lab’s...
OKAYAMA UNIVERSITY IMAGE: SCIENTISTS REPORT THAT METFORMIN, USED TO TREAT TYPE 2 DIABETES MELLITUS, INDUCES ACTIVATION AND PROLIFERATION OF TUMOR-TARGETING CD8+ T-LYMPHOCYTES (CD8TIL), VIA MECHANISMS THAT INVOLVE THE GENERATION OF REACTIVE OXYGEN SPECIES IN MITOCHONDRIA OF CD8TIL AND AN INCREASE IN GLYCOLYSIS. CREDIT: HEIICHIRO UDONO FROM OKAYAMA UNIVERSITY Modern medicine has made slow progress in...
Now that we find ourselves in an era in which there is growing support and funding for the treatment of aging as a medical condition, the battle ceases to be one of persuading people to take the idea seriously, and more a matter of convincing research and development concerns to focus on projects that are more likely rather...
Miriam E. Tucker August 03, 2021 Nearly half of adults prescribed metformin after a new diagnosis of type 2 diabetes have stopped taking it by 1 year, new data show. The findings, from a retrospective analysis of administrative data from Alberta, Canada, during 2012-2017, also show that the fall-off in metformin adherence was most dramatic during the first 30 days, and...
Heidi Splete July 15, 2021 The use of metformin was associated with a significant reduction in the risk of developing basal cell carcinoma (BCC), based on data from a population case-control study in Iceland. “In addition to general anticarcinogenic effects, metformin has also been shown to directly inhibit the sonic hedgehog pathway, a key pathway in basal...
by University of North Carolina Health Care HIV infecting a human cell. Credit: NIH A team led by scientists at the UNC School of Medicine discovered an important vulnerability of the AIDS-causing retrovirus HIV, and has shown in preclinical experiments that a widely used diabetes drug, metformin, seems able to exploit this vulnerability. The scientists, whose...
