by Impact Journals LLC Variable changes in phosphorylation of S6 kinase 1 was observed in both cohorts. Credit: Oncotarget (2023). DOI: 10.18632/oncotarget.28458 A new research paper titled “Utilizing metformin to prevent metabolic syndrome due to androgen deprivation therapy (ADT): a randomized phase II study of metformin in non-diabetic men initiating ADT for advanced prostate cancer” has been published in Oncotarget ....
by Impact Journals LLC Summary schematic of MET+LEU effects during SD in muscle cells. Credit: 2023 Petrocelli et al. Aging coincides with the accumulation of senescent cells within skeletal muscle that produce inflammatory products, known as the senescence-associated secretory phenotype, but the relationship of senescent cells to muscle atrophy is unclear. Previously, researchers found that...
BY JOSEPH GUSTAITIS | DECEMBER 30, 2022 Metformin, the most popular blood sugar-lowering medicine in the world, seems to be turning out to be the Swiss Army knife of medications. In recent years, there have been reports that metformin appears to improve mitochondrial function in people with diabetes, that it can help in chronic kidney disease (CKD), and...
by University of Barcelona The study identifies the cytokine GDF15, a protein whose expression increases in response to cellular stress, as a key factor for the metformin drug to show antidiabetic effects. Credit: Pharmacological Research (2022). DOI: 10.1016/j.phrs.2022.106578 Metformin, the most prescribed drug for treating diabetes mellitus, known as type 2 diabetes, requires the presence of the...
UNIVERSITY OF MINNESOTA MEDICAL SCHOOL Published in the New England Journal of Medicine, researchers — led by the University of Minnesota Medical School and School of Public Health — have found that metformin, a commonly prescribed diabetes medication, lowers the odds of emergency department visits, hospitalizations, or death due to COVID-19 by over 40 percent; and...
Marlene Busko, for Medscape July 28, 2022 The study covered in this summary was published on medRxiv as a preprint and has not yet been peer reviewed. Key Takeaways In an observational study of more than 112,000 US residents aged 50 years or older with type 2 diabetes, new users of metformin had about a 20% lower rate of incident...
THE ENDOCRINE SOCIETY Patients with type 2 diabetes have an increased risk for fractures, despite their normal-to-high bone mineral density, according to research being presented Saturday, June 11 at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga. “Patients using insulin or sulfonylurea are at a high risk of fractures compared to metformin-only users,...
Yale researchers have further elucidated the mechanism of metformin, a widely used type 2 diabetes medication that, despite its long history of being safe and effective, works in a way that has remained elusive to scientists. On March 1, Gerald Shulman, MD, PhD, George R. Cowgill Professor of Medicine (Endocrinology) and professor of cellular and molecular physiology, published his lab’s...
OKAYAMA UNIVERSITY IMAGE: SCIENTISTS REPORT THAT METFORMIN, USED TO TREAT TYPE 2 DIABETES MELLITUS, INDUCES ACTIVATION AND PROLIFERATION OF TUMOR-TARGETING CD8+ T-LYMPHOCYTES (CD8TIL), VIA MECHANISMS THAT INVOLVE THE GENERATION OF REACTIVE OXYGEN SPECIES IN MITOCHONDRIA OF CD8TIL AND AN INCREASE IN GLYCOLYSIS. CREDIT: HEIICHIRO UDONO FROM OKAYAMA UNIVERSITY Modern medicine has made slow progress in...
Now that we find ourselves in an era in which there is growing support and funding for the treatment of aging as a medical condition, the battle ceases to be one of persuading people to take the idea seriously, and more a matter of convincing research and development concerns to focus on projects that are more likely rather...
