by Tim Tedeschi, University of Cincinnati Credit: Unsplash/CC0 Public Domain A new large-scale study led by researchers at the University of Cincinnati and Northwell Health, New York’s largest health care provider, found the drug metformin can help prevent or reduce weight gain in youth taking medication to treat bipolar disorder. The collaborative team presented its findings...
Joshua J. Neumiller, PharmD, CDCES; Radica Z. Alicic, MD, MSc DISCLOSURES August 15, 2023Initially approved by the US Food and Drug Administration (FDA) in 1994, metformin has been the preferred first-line glucose-lowering agent for patients with type 2 diabetes (T2D) owing to its effectiveness, low hypoglycemia risk, weight neutrality, long clinical track record of safety,...
Joshua J. Neumiller, PharmD, CDCES; Radica Z. Alicic, MD, MSc Initially approved by the US Food and Drug Administration (FDA) in 1994, metformin has been the preferred first-line glucose-lowering agent for patients with type 2 diabetes (T2D) owing to its effectiveness, low hypoglycemia risk, weight neutrality, long clinical track record of safety, and affordability. However,...
by Impact Journals LLC Variable changes in phosphorylation of S6 kinase 1 was observed in both cohorts. Credit: Oncotarget (2023). DOI: 10.18632/oncotarget.28458 A new research paper titled “Utilizing metformin to prevent metabolic syndrome due to androgen deprivation therapy (ADT): a randomized phase II study of metformin in non-diabetic men initiating ADT for advanced prostate cancer” has been published in Oncotarget ....
by Impact Journals LLC Summary schematic of MET+LEU effects during SD in muscle cells. Credit: 2023 Petrocelli et al. Aging coincides with the accumulation of senescent cells within skeletal muscle that produce inflammatory products, known as the senescence-associated secretory phenotype, but the relationship of senescent cells to muscle atrophy is unclear. Previously, researchers found that...
BY JOSEPH GUSTAITIS | DECEMBER 30, 2022 Metformin, the most popular blood sugar-lowering medicine in the world, seems to be turning out to be the Swiss Army knife of medications. In recent years, there have been reports that metformin appears to improve mitochondrial function in people with diabetes, that it can help in chronic kidney disease (CKD), and...
by University of Barcelona The study identifies the cytokine GDF15, a protein whose expression increases in response to cellular stress, as a key factor for the metformin drug to show antidiabetic effects. Credit: Pharmacological Research (2022). DOI: 10.1016/j.phrs.2022.106578 Metformin, the most prescribed drug for treating diabetes mellitus, known as type 2 diabetes, requires the presence of the...
UNIVERSITY OF MINNESOTA MEDICAL SCHOOL Published in the New England Journal of Medicine, researchers — led by the University of Minnesota Medical School and School of Public Health — have found that metformin, a commonly prescribed diabetes medication, lowers the odds of emergency department visits, hospitalizations, or death due to COVID-19 by over 40 percent; and...
Marlene Busko, for Medscape July 28, 2022 The study covered in this summary was published on medRxiv as a preprint and has not yet been peer reviewed. Key Takeaways In an observational study of more than 112,000 US residents aged 50 years or older with type 2 diabetes, new users of metformin had about a 20% lower rate of incident...
THE ENDOCRINE SOCIETY Patients with type 2 diabetes have an increased risk for fractures, despite their normal-to-high bone mineral density, according to research being presented Saturday, June 11 at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga. “Patients using insulin or sulfonylurea are at a high risk of fractures compared to metformin-only users,...
