Yale researchers have further elucidated the mechanism of metformin, a widely used type 2 diabetes medication that, despite its long history of being safe and effective, works in a way that has remained elusive to scientists. On March 1, Gerald Shulman, MD, PhD, George R. Cowgill Professor of Medicine (Endocrinology) and professor of cellular and molecular physiology, published his lab’s...
Tag: <span>Metformin</span>
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When cancer “met” its match: New study shows metformin-dependent antitumor immunity
OKAYAMA UNIVERSITY IMAGE: SCIENTISTS REPORT THAT METFORMIN, USED TO TREAT TYPE 2 DIABETES MELLITUS, INDUCES ACTIVATION AND PROLIFERATION OF TUMOR-TARGETING CD8+ T-LYMPHOCYTES (CD8TIL), VIA MECHANISMS THAT INVOLVE THE GENERATION OF REACTIVE OXYGEN SPECIES IN MITOCHONDRIA OF CD8TIL AND AN INCREASE IN GLYCOLYSIS. CREDIT: HEIICHIRO UDONO FROM OKAYAMA UNIVERSITY Modern medicine has made slow progress in...
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Metformin Remains a Poor Choice in the Treatment of Aging
Now that we find ourselves in an era in which there is growing support and funding for the treatment of aging as a medical condition, the battle ceases to be one of persuading people to take the idea seriously, and more a matter of convincing research and development concerns to focus on projects that are more likely rather...
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Half Abandon Metformin Within a Year of Diabetes Diagnosis
Miriam E. Tucker August 03, 2021 Nearly half of adults prescribed metformin after a new diagnosis of type 2 diabetes have stopped taking it by 1 year, new data show. The findings, from a retrospective analysis of administrative data from Alberta, Canada, during 2012-2017, also show that the fall-off in metformin adherence was most dramatic during the first 30 days, and...
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Metformin Use May Curb BCC Risk
Heidi Splete July 15, 2021 The use of metformin was associated with a significant reduction in the risk of developing basal cell carcinoma (BCC), based on data from a population case-control study in Iceland. “In addition to general anticarcinogenic effects, metformin has also been shown to directly inhibit the sonic hedgehog pathway, a key pathway in basal...
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Another use for Metformin
by University of North Carolina Health Care HIV infecting a human cell. Credit: NIH A team led by scientists at the UNC School of Medicine discovered an important vulnerability of the AIDS-causing retrovirus HIV, and has shown in preclinical experiments that a widely used diabetes drug, metformin, seems able to exploit this vulnerability. The scientists, whose...
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Use of goldenseal may compromise glucose control in diabetics on metformin
WASHINGTON STATE UNIVERSITY SPOKANE, Wash. – Diabetic patients taking the natural product goldenseal while taking the prescription drug metformin may be unwittingly sabotaging their efforts to maintain healthy blood glucose levels. This concern arose from a recent study published in the journal Clinical Pharmacology & Therapeutics. Metformin–the world’s most-prescribed oral glucose-lowering medication–was included in a cocktail of selected drugs...
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Recall report: Nostrum recalls another lot of metformin as carcinogen concerns continue
Conner Mitchell Associate Editor For the second time in January and the third time in the last two months, a Kansas City, MO laboratory has pulled a lot of generic metformin from the shelves after it was found to contain higher-than-allowed levels of a probable human carcinogen. The FDA on Tuesday announced that Nostrum Laboratories was voluntarily...
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Metformin use reduces risk of death for patients with COVID-19 and diabetes
UNIVERSITY OF ALABAMA AT BIRMINGHAM IMAGE: ANATH SHALEV CREDIT: UAB BIRMINGHAM, Ala. – Use of the diabetes drug metformin — before a diagnosis of COVID-19 — is associated with a threefold decrease in mortality in COVID-19 patients with Type 2 diabetes, according to a racially diverse study at the University of Alabama at Birmingham. Diabetes...
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Nostrum expands recall of diabetes drug metformin after carcinogen concerns
Conner Mitchell Associate Editor Generic metformin has been a thorn in drugmakers’ sides for months after a probable human carcinogen was found in tested lots. Now, one of the companies is expanding its recall to another lot of the drug. Nostrum Laboratories out of Kansas City, MO voluntarily recalled one lot of metformin HCl extended release...