by Tim Tedeschi, University of Cincinnati Bacterial species diversity in long-term survivors (LTSs) versus controls. (A) Principal coordinates ordination performed on the species-level Bray-Curtis dissimilarity for LTSs and controls. (B) Shannon and Simpson indices for species diversity in LTSs versus controls. Credit: Cancer (2023). DOI: 10.1002/cncr.34748 Even as pancreatic cancer treatments improve, only about 9% of patients survive past five...
Tag: <span>Microbiome</span>
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Chronic fatigue syndrome is associated with distinct changes in the microbiome
by Cell Press Graphical abstract. Credit: Cell Host & Microbe (2023). DOI: 10.1016/j.chom.2023.01.001 Over the past three years, the emergence of long-term effects associated with COVID-19 has led to increased focus on a disease with similar hallmarks and symptoms—myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Two studies publishing February 8 in the journal Cell Host & Microbe are taking a closer...
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Researchers link ovarian cancer to bacteria colonization in microbiome
by Susan Murphy, Mayo Clinic β-diversities measures were compared. For β-diversity, Bray–Curtis (BC), unweighted, and weighted, UniFrac distance metrics were reported. The most significant metric is shown in each ordination plot. (A–D) Bacterial community β-diversity between OC patients with sensitive vs other (resistant/refractory) tumor response. Fallopian tube, (A) β-diversity: sensitive vs other (p = 0.003). Ovaries, (B)...
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Your microbiome ages as you do—and that’s a problem
KATERYNA KON/SCIENCE PHOTO LIBRARY VIA GETTY This article is from The Checkup, MIT Technology Review’s weekly biotech newsletter. We’re all crawling with bugs. Our bodies are home to plenty of distinct ecosystems that are home to microbes, fungi, and other organisms. They are crucial to our well-being. Shifts in the microbiome have been linked to...
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The gut microbiome’s supersized role in shaping molecules in our blood
by Institute for Systems Biology Credit: Pixabay/CC0 Public Domain Scientists from the Institute for Systems Biology (ISB) have shown which blood metabolites are associated with the gut microbiome, genetics, or the interplay between both. Their findings will be published in the journal Nature Metabolism and have promising implications for guiding targeted therapies designed to alter the composition...
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Study finds antibiotics may make melanoma worse, by depleting the gut microbiome
by American Society for Bone and Mineral Research Credit: CC0 Public Domain The use of broad-spectrum antibiotics in mice with malignant melanoma, an aggressive form of skin cancer, accelerated their metastatic bone growth, likely because the drugs depleted the mice’s intestinal flora and weakened their immune response, according to a new study by researchers at...
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Food allergies can be reversed in mice by targeting the microbiome
by American Chemical Society Credit: Pixabay/CC0 Public Domain Although many people with dietary allergies experience mild symptoms when exposed to triggering foods, some face potentially fatal consequences. A bacterial compound called butyrate that’s made by healthy microbiomes has shown promise against allergic reactions in lab tests, but it’s nasty to take orally. Today, scientists describe...
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Engineering the microbiome to potentially cure disease
UNIVERSITY OF CALIFORNIA – SAN DIEGO IMAGE: AN ARTIST’S RENDERING OF THE CONCEPT OF RE-ENGINEERED NATIVE BACTERIA THAT SERVE AS CHASSIS TO INTRODUCE THERAPEUTICS INTO THE GUT MICROBIOME TO TREAT OR CURE DISEASE. CREDIT: THOM LEACH, AMOEBA STUDIOS Residing within the human gut are trillions of bacteria and other microorganisms that can impact a variety...
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Butyrate in microbiome abates a host of ills, studies find
While there are routine reminders to eat fiber, whole foods, suitable vegetables, and carbohydrates, one important topic is typically left out of the conversation on a diet for a healthy gut, said Dr. Chris Damman, a gastroenterologist with the University of Washington School of Medicine. He studies the effect of nutrition on health by way of the microbiome....
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Another secret of fibromyalgia discovered in microbiome
by McGill University Health Centre Credit: Pixabay/CC0 Public Domain Affecting up to four percent of the population and mostly women, fibromyalgia is a syndrome that causes pain, fatigue and cognitive issues. Poorly understood, the condition has no cure and is difficult to diagnose. Now, thanks to the work of a team of scientists from the...