by New York University An illustration of the pain signaling pathway elicited by CGRP. CGRP activates the CGPR receptor on Schwann cells. The CGPR receptor traffics to endosomes, where sustained signaling results in the release of nitric oxide. Nitric oxide targets ion channel TRPA1 in Schwann cells, which excites the neuron and transmits pain signals...
Erik Greb June 08, 2021 A non-invasive, self-administered neurostimulation device recently approved by the US Food and Drug Administration (FDA) is safe, tolerable, and offers “highly effective” pain relief in acute migraine, new research shows. Results of a randomized, sham-controlled trial show 46% of patients with acute migraine achieved complete freedom from pain 2 hours after treatment...
by Adrienne Williamson, Medical Xpress CGRP receptor signaling complex structure. Visualization provided by Patrick M. Sexton, PhD. A research team with members from Monash University, the ARC Centre for Cryo-electron Microscopy of Membrane Proteins, the University of Tokyo and the University of Otago have determined the shape and kinetics of an important cell surface (membrane) receptor called...
Ketamine, a medication commonly used for pain relief and increasingly used for depression, may help alleviate migraine pain in patients who have not been helped by other treatments, suggests a study being presented at the ANESTHESIOLOGY® 2017 annual meeting. The study of 61 patients found that almost 75 percent experienced an improvement in their migraine...
