MAY 22ND, 2023 CONN HASTINGS DIAGNOSTICS, MEDICINE, NEUROLOGY Scientists at the University of Minnesota have developed a method to detect misfolded proteins more rapidly and sensitively. The technique could eventually allow clinicians to diagnose diseases that involve misfolded proteins more easily, including Alzheimer’s, Parkinson’s, and Creutzfeldt-Jakob disease. The approach involves an enhancement to an existing assay...
BY ELISE OVERGAARD Misfolded proteins are toxic to cells. They disrupt normal functions and cause some age-related human degenerative diseases, like Alzheimer’s, Parkinson’s, and Huntington’s diseases. Cells work constantly to eliminate misfolded proteins, but these clearance mechanisms are still poorly understood. In a new study published April 20 in Nature Cell Biology, researchers at Stanford University discovered a previously unknown...
by Baylor College of Medicine Misfolded proteins can grow into a variety of aggregate forms, such as soluble aggregates, soluble polymers and insoluble polymers, which may be disposed of via different mechanisms, including unconventional disposal, extracellular vesicles and autophagy. When the cellular disposal mechanisms fail, such aggregates may lead to disease. About 30 years ago, Dr....
