by The Scripps Research Institute Alzheimer’s nerve cells manifest a decrease in the connections between nerve cells, called synapses, shown here within the blue circles. Half the synapse is marked with a red fluorescent stain and the other half with a yellow stain. Credit: Scripps ResearchNerve cells in the brain demand an enormous amount of energy...
by University of California – San Diego These colored streaks are mitochondrial networks within fat cells. Researchers from UC San Diego discovered that a high-fat diet dismantles mitochondria, resulting in weight gain. Credit: UC San Diego Health SciencesThe number of people with obesity has nearly tripled since 1975, resulting in a worldwide epidemic. While lifestyle factors...
What causes fatigue after exercise in people with long COVID? Image credit: M Stone/Stocksy.At least 65 million people globally have long COVID.The most common symptoms of long COVID include post-exertional malaise, cognitive impairment, brain fog, sleep problems, and fatigue, which can have a severe impact on a person’s life.Researchers are still unsure why some people...
Peer-Reviewed Publication UNIVERSITY OF COLOGNE PICTURES SHOW SMALL INTESTINAL VILLI FROM WILD TYPE (TOP) AND ENTEROCYTE-SPECIFIC DARS2 KNOCKOUT MICE (BOTTOM) STAINED FOR PLIN2 (YELLOW), TGN38 (RED), E-CADHERIN (GREEN) AND DNA (DAPI, BLUE). CREDIT: CHRYSANTHI MOSCHANDREA The maintenance of a balanced lipid homeostasis is critical for our health. While consumption of excessive amounts of fatty foods...
Nov 10 2023São Paulo Research Foundation (FAPESP) Researchers at the University of São Paulo (USP) in Brazil, partnering with colleagues in Australia, have identified a novel bacterial protein that can keep human cells healthy even when the cells have a heavy bacterial burden. The discovery could lead to new treatments for a wide array of...
by Julius-Maximilians-Universität Würzburg a Adoptive co-transfer of WT (tdTomato+GFP+) and HIF-1α-deficient (tdTomato+) P14 T cells into C57BL/6 mice before chronic infection with LCMV clone 13 (LCMVCL13). 21 days post infection (d.p.i.), donor P14 WT and HIF-1α-deficient T cells were FACS sorted, barcoded, and multiplexed in a 1:1 ratio and subjected to single-cell RNA sequencing. Uniform manifold...
by Laval University Endogenous mitochondrial mass in FECD cells influences mitochondrial internalization. (A) Mitochondrial mass markers (mitotracker) were used to label exogenous internalized (green) and endogenous mitochondria (red). (B) Both mitotracker signals were plotted, each dot representing a single cell. The mitochondrial mass appeared to be distributed according to two distinct clusters that could be arbitrarily...
by Salk Institute Electron microscopic image of neurons in the brain showing the presynaptic boutons (yellow), mitochondria (purple), and synapses (blue). Credit: Salk Institute Brains are like puzzles, requiring many nested and co-dependent pieces to function well. The brain is divided into areas, each containing many millions of neurons connected across thousands of synapses. These synapses,...
by University of Chicago Medical Center Loss of BNIP3 promotes HCC initiation and tumor growth. (A) Representative images of HCC tumors forming in the liver of Bnip3+/+ and bnip3−/− mice at 24 and 40 weeks of age following DEN injection. Scale bars, 12.7 mm. (B) Graph of tumor number forming in the liver of Bnip3+/+ (red) and bnip3−/− (blue)...
by The Wistar Institute Differential expression of a Mic60-low gene signature in cancer. Credit: PLOS ONE (2022). DOI: 10.1371/journal.pone.0273520 The mitochondria is a key energy-producing component of the human cell that plays an important role in cancer cell metabolism. In a research paper published in PLOS ONE, Dario C. Altieri, M.D., president and chief executive officer, director of...
