by Laval University Endogenous mitochondrial mass in FECD cells influences mitochondrial internalization. (A) Mitochondrial mass markers (mitotracker) were used to label exogenous internalized (green) and endogenous mitochondria (red). (B) Both mitotracker signals were plotted, each dot representing a single cell. The mitochondrial mass appeared to be distributed according to two distinct clusters that could be arbitrarily...
by Salk Institute Electron microscopic image of neurons in the brain showing the presynaptic boutons (yellow), mitochondria (purple), and synapses (blue). Credit: Salk Institute Brains are like puzzles, requiring many nested and co-dependent pieces to function well. The brain is divided into areas, each containing many millions of neurons connected across thousands of synapses. These synapses,...
by University of Chicago Medical Center Loss of BNIP3 promotes HCC initiation and tumor growth. (A) Representative images of HCC tumors forming in the liver of Bnip3+/+ and bnip3−/− mice at 24 and 40 weeks of age following DEN injection. Scale bars, 12.7 mm. (B) Graph of tumor number forming in the liver of Bnip3+/+ (red) and bnip3−/− (blue)...
by The Wistar Institute Differential expression of a Mic60-low gene signature in cancer. Credit: PLOS ONE (2022). DOI: 10.1371/journal.pone.0273520 The mitochondria is a key energy-producing component of the human cell that plays an important role in cancer cell metabolism. In a research paper published in PLOS ONE, Dario C. Altieri, M.D., president and chief executive officer, director of...
by University of California – San Diego A colorized transmission electron micrograph depicts cellular mitochondria with its characteristic internal folds called cristae. Credit: Thomas Deerinck, National Center for Microscopy and Imaging Research, UC San Diego Mitochondria are self-contained organelles (they possess their own mini-chromosome and DNA) residing within cells and are charged with the job of...
by German Cancer Research Center A hairpin loop from a pre-mRNA. Highlighted are the nucleobases (green) and the ribose-phosphate backbone (blue). Note that this is a single strand of RNA that folds back upon itself. Credit: Vossman/ Wikipedia Mitochondria are the power plants of cells, and they contain their own genetic material and RNA molecules....
by Kyrie Wilson, Medical University of South Carolina Mitochondria (shown in red) are damaged and degraded (shown in green) upon ethanol exposure (right) that is not seen under normal conditions (left). Credit: Drs. Lemasters and Zhong / MUSC While most commonly known as “the powerhouses of the cell” because of their energy producing capabilities, mitochondria also...
When we eat and then digest a meal, the nutrients and other useful components in the food are broken down—or metabolized—and ultimately make their way to cells throughout the body. Each cell has its own power plant, called the mitochondria, which produces energy for the cell’s various processes as well as other tasks that help keep...
by Greg Glasgow, CU Anschutz Medical Campus MIRO1/2 alterations in cancer. A, The TCGA database was interrogated for MIRO1/2 mRNA expression across tumor types. PanCA, PanCancer. B, Relative expression of MIRO1/2 mRNA in cancer versus normal adjacent tissues on the prostate TCGA PanCancer study. C, Kaplan–Meier analyses based on MIRO1/2 mRNA expression in human primary...
CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.) IMAGE: ANA VICTORIA LECHUGA-VIECO, RAQUEL JUSTO, JOSÉ ANTONIO ENRÍQUEZ, JESÚS VÁZQUEZ Y ENRIQUE CALVO. CREDIT: CNIC Research carried out at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has demonstrated that mixing mitochondrial DNAs (mtDNAs) of different origins can have damaging effects over the medium and long term. mtDNA is...
