by Asociacion RUVID Metformin 500mg tablets. Credit: public domain A research team from the Department of Physiology of the University of Valencia, the FISABIO foundation, and University Hospital Dr. Peset have proven that the mitochondrial dysfunction that occurs in type-2 diabetes can be countered with metformin. The study is published in Antioxidants & Redox Signaling. Mitochondria...
by Karolinska Institutet Methylation is a small protein modification that uses SAM as a co-factor. This study shows how SAM is required for mitochondrial function in various organisms. Credit: Karolinska Institutet. Disorders of cellular energy supply can cause a number of serious diseases, but also seem to be connected to aging. More research is needed on mitochondrial function...
KAROLINSKA INSTITUTET IMAGE: METHYLATION IS A SMALL PROTEIN MODIFICATION THAT USES SAM AS A CO-FACTOR. THIS STUDY SHOWS HOW SAM IS REQUIRED FOR MITOCHONDRIAL FUNCTION IN VARIOUS ORGANISMS. CREDIT: KAROLINSKA INSTITUTET. Disorders of the cells’ energy supply can cause a number of serious diseases, but also seem to be connected to ageing. More research is needed on...
Here, researchers explore the mechanisms governing changes in cell behavior during reprogramming. Many of the aspects of aging found in cells taken from old tissues can be reversed via the process of reprogramming these cells into induced pluripotent stem cells. Mitochondrial function is restored to youthful levels, for example, as well as much of the epigenetic signature that determines protein production and...
Chronic inflammation grows with age throughout the body, characterized by increased levels of numerous inflammatory signal molecules, among which is IL-6. One contributing factor to the chronic inflammation of aging is the accumulation of lingering senescent cells, which rouse the immune system via secreted molecules that include, prominently, IL-6. Researchers here home in on one narrow consequence of...
