by RIKEN Figure 1: Colored transmission electron micrograph of a single mitochondrion in a human pancreas cell. RIKEN researchers have developed a fluorescent probe that can detect the programmed death of defective mitochondria in the lysosomes. Credit: K.R. PORTER/ SCIENCE PHOTO LIBRARY A versatile probe that can detect with pinpoint accuracy the programmed destruction of...
TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE DAMAGED MITOCHONDRIA ARE SELECTIVELY ELIMINATED VIA AUTOPHAGY CALLED MITOPHAGY. IN MAMMALIAN CELLS, UBIQUITIN CHAINS ON THE DAMAGED MITOCHONDRIA PLAY CRITICAL ROLES TO INDUCE MITOPHAGY. Researchers at TMIMS have revealed that PINK1 (a serine/threonine kinase) and Parkin (a ubiquitin ligating enzyme: E3) work together to ubiquitylate the outer membrane proteins...
Supplements of the drug NAD+ may offer a new way of attacking Werner Syndrome, according to a study with animal models Patients with Werner Syndrome have early signs of aging, such as grey hair, wrinkled skin, and increased incidence of cancer and type 2 diabetes. On average, they die at the age of 45. The...
