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The human spliceosome: Decade-long study reveals first blueprint of the most complex molecular machine inside every cell

by Center for Genomic Regulation Dr. Malgorzata Rogalska studying cell cultures at the Centre for Genomic Regulation in Barcelona. Credit: Centro de Regulación Genómica Researchers at the Center for Genomic Regulation (CRG) in Barcelona have created the first blueprint of the human spliceosome, the most complex and intricate molecular machine inside every cell. The scientific feat,...

A molecular machine’s secret weapon exposed
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A molecular machine’s secret weapon exposed

COLD SPRING HARBOR LABORATORY IMAGE: KATARINA MEZE, THE FORMER GRADUATE STUDENT IN THE JOSHUA-TOR LAB WHO LED THIS STUDY, STANDING NEXT TO THE LAB’S CRYO-EM IMAGING MACHINE. THE MACHINE ALLOWS SCIENTISTS TO FREEZE MOLECULES IN PLACE TO STUDY THEIR STRUCTURE AND GEOMETRY. CREDIT: JOSHUA-TOR LAB/CSHL RNAs are having a moment. The foundation of COVID-19 vaccines,...