SCIENCE & TECHNOLOGY NEWS A new technique developed by McGill researchers for mechanically manipulating stem cells could lead to new stem cell treatments, which have yet to fulfill their therapeutic potential. Surgery – illustrative photo. Image credit: Max Pixel, CC0 Public Domain Stem cell therapy has been heralded as a new way to treat many...
By Kevin Dennehy August 28, 2024 A Yale-led study reveals a mechanism that triggers loss of immune regulation associated with multiple sclerosis and other diseases — and a target for treatment. (© stock.adobe.com) More than two decades ago, a research team in the lab of David Hafler, a Yale researcher who at the time was...
by University of Pittsburgh Credit: Unsplash/CC0 Public DomainUniversity of Pittsburgh School of Medicine researchers discovered a molecular mechanism by which excessive dietary protein could increase atherosclerosis risk. The findings were published in Nature Metabolism. The study, which combined small human trials with experiments in mice and cells in a Petri dish, showed that consuming over 22%...
MASSACHUSETTS GENERAL HOSPITAL BOSTON – Mass General researchers have discovered a novel molecular mechanism responsible for the most common forms of acquired hydrocephalus, potentially opening the door to the first-ever nonsurgical treatment for a life-threatening disease that affects about a million Americans. As reported in the journal Cell, the team uncovered in animal models the pathway through which infection or...
by University of Montreal Credit: CC0 Public Domain In a crucial step towards understanding the mechanisms involved in cardiovascular disease and certain cancers, a Canadian led research team has succeeded in a world first: they’ve found the molecular mechanism by which the protein PCSK9 degrades the receptor of low density lipoproteins, the richest cholesterol particles in the...
by University of Barcelona The paper states that the lack of interaction between two neuronal adenosine receptors may be responsible for the disruption of neuronal circuits in early or juvenile Parkinson’s disease. Credit: Biomedicine & Pharmacotherapy (2022). DOI: 10.1016/j.biopha.2022.113896 Parkinson’s disease affects 3% of population over 65 years old, and the average age of onset is 60....
OSAKA UNIVERSITY IMAGE: NOVEL MECHANISM OF INTRAHEPATIC CHOLANGIOCARCINOMA DEVELOPMENT THROUGH TRANSDIFFERENTIATION OF HEPATOCYTES THROUGH DYSREGULATION OF TRAF3/NIK SIGNALING. CREDIT: YUTO SHIODE ET AL. Osaka, Japan – In a recent article published in Hepatology, a group led by researchers at Osaka University investigated the molecular mechanisms that drive development of Intrahepatic cholangiocarcinoma (ICC) – a cancer which...
by Kanazawa University Microenvironment at the initiation stage of breast cancer carcinogenesis generated by FRS2β. Cancer stem cells emerging in the initial microenvironment of the mammary gland of the breast cancer mouse model MMTV-ErbB2 proliferate to form a tumor mass (left). On the other hand, MMTV-ErbB2/Frs2β -/- mammary glands lacking FRS2β do not form such...
by University of California, Irvine “This study is the first to identify that NAAA, a previously unrecognized control node, can be effectively targeted by small-molecule therapeutics that inhibit this enzyme, and block the transition from acute to chronic pain,” said Daniele Piomelli, Ph.D., Distinguished Professor in the UCI School of Medicine Department of Anatomy & Neurobiology....
IMAGE: RUTGERS RESEARCHERS HAVE DISCOVERED SOME OF THE FIRST MOLECULAR INSIGHTS INTO HOW TOXIC PROTEINS ARE REGULATED IN NEURODEGENERATIVE DISEASES SUCH AS ALZHEIMER’S AND PARKINSON’S. CREDIT: SHUTTERSTOCK New Brunswick, N.J. (Sept. 13, 2021) – Rutgers researchers have discovered some of the first molecular insights into how toxic proteins are regulated in neurodegenerative diseases such as Alzheimer’s and...
