by Osaka University Figure 1. (Left panel) Flow chart demonstrating dendritic cells (DCs) in wildtype (WT) and DC-specific Lamtor1-KO mice. In the absence of Lamtor1, skin-draining lymph nodes showed reduced numbers of migratory DCs. (Right panel) Representative images of the skin of WT and Lamtor1-KO mice. In the absence of Lamtor1, the contact dermatitis was impaired...
Prolonged overactivity of killer T cells summoned to a tumor or infection site can render them useless to dispatch invaders, a cellular state immunologists call “exhaustion.” Credit: National Institutes of Health One reason we survive into adulthood is that cell-killing T cells usually recognize and eliminate cancerous or pathogen-infected cells. But prolonged overactivity of...
